Osteocalcin associates with bone mineral density and VDR gene polymorphisms in type 1 and type 2 diabetes.

Autor:	Ramírez Ruiz C; Department of Clinical Biochemistry, Clínica Universidad de Navarra, Madrid, Spain.; Servicio de Bioquímica, Clínica Universidad de Navarra - Madrid, Madrid, Spain., Varo Cenarruzabeitia N; Department of Clinical Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain., Martínez Villanueva M; Department of Clinical Biochemistry, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Hernández Martínez AM; Endocrinology and Nutrition Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Noguera Velasco JA; Endocrinology and Nutrition Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Jazyk:	angličtina
Zdroj:	Advances in laboratory medicine [Adv Lab Med] 2023 Oct 24; Vol. 5 (1), pp. 46-55. Date of Electronic Publication: 2023 Oct 24 (Print Publication: 2024).
DOI:	10.1515/almed-2023-0131
Abstrakt:	Objectives: Bone metabolism is impaired in diabetes mellitus (DM). Our objective is to evaluate the association of bone turnover markers (BTM) and vitamin D receptor ( VDR ) gene polymorphisms with bone mineral density (BMD) in DM type 1 (T1D) and DM type 2 (T2D). Methods: A total of 165 patients (53 T1D and 112 T2D) were enrolled. BMD was measured by dual-energy X-ray absorptiometry (DEXA). Plasma osteocalcin (OC), beta-CrossLaps (β-CTX) and N-amino terminal propeptide of type I collagen (P1NP) and VDR gene polymorphisms were evaluated. Results: Participants were 53 T1D (41 years [31-48]) and 112 T2D (60 years [51-66]). BMD were not statistically different between the groups. OC (p<0.001) and P1NP levels (p<0.001) were higher in patients with T1D. The areas under the curve for the prediction of bone pathology were 0.732 (p=0.038) for OC in T1D and 0.697 (p=0.007) in T2D. A significant association was found between lower lumbar BMD and the A allele of BsmI (p=0.03), the A allele of ApaI (p=0.04) and the allele C of the Taql (p=0.046). Also, a significant correlation was found with higher OC levels and the G allele of BsmI (p=0.044), C allele of ApaI (p=0.011), T allele of Taql (p=0.006) and with C allele of FokI (p=0.004). Conclusions: The high negative predictive value of the cut-off point for OC suggests that could be useful in excluding the risk suffering bone loss, allowing offering a personalized clinical approach to prevent this pathology. Competing Interests: Competing interests: The authors state no conflict of interest. (© 2023 the author(s), published by De Gruyter, Berlin/Boston.)
Databáze:	MEDLINE
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