Blastoid Mantle Cell Lymphoma Presenting as an Oropharyngeal Mass.
| Autor: | Macapagal S; Internal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA., Wannaphut C; Internal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA., Takahashi T; Internal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA., Yinadsawaphan T; Internal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA., Nishimura Y; Internal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA., Acoba J; Hematology and Oncology, The Queen's Medical Center, Honolulu, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Mar 18; Vol. 16 (3), pp. e56378. Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.56378 |
| Abstrakt: | Blastoid mantle cell lymphoma (MCL) is an extremely rare neoplasm with a dismal prognosis. MCL with an initial presentation in the oral cavity has been rarely reported. This report describes a 75-year-old male who presented with an oropharyngeal mass causing dysphonia and intermittent hypoxia. A biopsy and immunophenotyping confirmed MCL, favoring the blastoid variant. Imaging showed a 4.2 cm left oropharyngeal polypoid mass with extensive lymphadenopathy. His prognosis was considered unfavorable with elevated Ki-67 index, blastoid morphology, and p53 positivity of malignant cells. There was no central nervous system involvement. He received palliative radiation, resulting in profound tumor reduction and resolution of symptoms. An intensive chemoimmunotherapy was not deemed beneficial due to age, comorbidities, absence of TP53 mutation, and a personal preference for a less aggressive treatment. This case highlights the importance of risk-adapted and personalized management approaches in a very unique presentation of blastoid MCL. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Macapagal et al.) |
| Databáze: | MEDLINE |
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