Molecular profiling of primary endometrioid endometrial cancer and matched lung metastases: CTNNB1 mutation as a potential driver.

Autor:	Gordhandas S; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Da Cruz Paula A; i3S Instituto de Investigação e Inovação em Saúde, Porto 4200-135, Portugal., Kertowidjojo EC; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, The University of Chicago, Chicago, IL, USA., Pareja F; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dessources K; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Obstetrics and Gynecology, UNC Health, Chapel Hill, NC, USA., da Silva EM; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Derakhshan F; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA., Mueller JJ; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Abu-Rustum NR; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chui MH; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Weigelt B; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Gynecologic oncology reports [Gynecol Oncol Rep] 2024 Apr 10; Vol. 53, pp. 101391. Date of Electronic Publication: 2024 Apr 10 (Print Publication: 2024).
DOI:	10.1016/j.gore.2024.101391
Abstrakt:	•Both primary endometrial cancers (ECs) and matched lung metastases shared a common ancestor with independent evolution at each site.•The two endometrioid ECs studied acquired additional mutations during the distant metastatic process.•Subclonal CTNNB1 hotspot mutations in the two primary ECs studied became clonal in the distant metastases. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [B. Weigelt reports research funding from Repare Therapeutics and employment of an immediate family member at AstraZeneca, outside the submitted work. F. Pareja is a member of the scientific advisory board of MultiplexDx, and a member of the diagnostic advisory board and speaker for AstraZeneca. N.R. Abu-Rustum reports research funding from GRAIL paid to Memorial Sloan Kettering Cancer Center.]. (© 2024 The Authors.)
Databáze:	MEDLINE
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