An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter.

Autor:	Vieira TDS; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Freitas FV; Department of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre, Brazil., Silva Neto LCB; Program of Post-Graduation in Nutrition and Health, Federal University of Espírito Santo, Vitória, Brazil., Borçoi AR; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Mendes SO; Department of Morphology, Federal University of Espirito Santo, Vitória, Brazil., Olinda AS; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Moreno IAA; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Quaioto BR; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., de Souza MLM; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Barbosa WM; Department of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre, Brazil., Arpini JK; Department of Biology, Federal University of Espirito Santo, Alegre, Brazil., Sorroche BP; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., de Assis Pinheiro J; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Archanjo AB; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Dos Santos JG; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil., Arantes LMRB; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., de Oliveira DR; Department of Pharmacology and Medical Toxicology, College of Wisconsin, Milwaukee, WI, United States., da Silva AMA; Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, Brazil.; Department of Morphology, Federal University of Espirito Santo, Vitória, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2024 Apr 03; Vol. 11, pp. 1168715. Date of Electronic Publication: 2024 Apr 03 (Print Publication: 2024).
DOI:	10.3389/fnut.2024.1168715
Abstrakt:	Background: Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms. Objective: Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS). Methods: We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40-47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models ( p  < 0.05). Lifestyle variables and health variables were included as confounding factors. Results: The findings of our cross-sectional study indicated an association between NR3C1 DNA methylation and intake of processed foods. We also observed relevant associations of average NR3C1 DNA across the segment analyzed, methylation in component 1 (40-43), and methylation in component 2 (44-47) with a pattern of consumption of industrialized products in relation to BMI, serum cortisol levels, and lipid profile. These results may indicate a relationship between methylation and metabolic changes related to the stress response. Conclusion: These findings suggest an association of methylation and metabolic alterations with stress response. In addition, the present study highlights the significant role of diet quality as a stress-inducing factor that influences NR3C1 methylation. This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Vieira, Freitas, Silva Neto, Borçoi, Mendes, Olinda, Moreno, Quaioto, de Souza, Barbosa, Arpini, Sorroche, de Assis Pinheiro, Archanjo, dos Santos, Arantes, de Oliveira and da Silva.)
Databáze:	MEDLINE
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