Retrospective Evaluation of Risk Factors for Invasive Candida Infections in a Medical Intensive Care Unit.
| Autor: | Bilgin MK; Tokat Erbaa State Hospital, Tokat, Turkey., Talan L; Department of Internal Medicine, Division of Intensive Care, Ankara University School of Medicine, Ankara, Turkey., Evren E; Department of Microbiology, Ankara University School of Medicine, Ankara, Turkey., Altıntaş ND; Department of Internal Medicine, Division of Intensive Care, Ankara University School of Medicine, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Infectious diseases & clinical microbiology [Infect Dis Clin Microbiol] 2022 Feb 14; Vol. 4 (1), pp. 62-71. Date of Electronic Publication: 2022 Feb 14 (Print Publication: 2022). |
| DOI: | 10.36519/idcm.2022.56 |
| Abstrakt: | Objective: We aimed to detect the risk factors for invasive candida infections by evaluating the fungal strains cultivated from samples taken in a medical intensive care unit (ICU). Materials and Methods: We investigated fungal growths between January 1, 2016, and December 1, 2018, retrospectively. All reported fungal growths and demographic characteristics, clinical features, treatments and outcomes of the patients with fungal growths were recorded. Results: Fungal growths were reported from 384 different samples obtained from 179 ICU patients. The most common strain was determined to be C. albicans (47.9%).The incidence of non- albicans Candida strains was increased over the years (2016 - 44%, 2017 - 52.5%, 2018 - 49%), most significantly C. glabrata (7.7% to 14.6%). The most common strain was C. parapsilosis (57.9%) in patients with candidemia, and infection was more severe among them. Fluconazole resistance was rare. When patients with and without fungal growth were compared, a significant difference was found between groups in terms of age, acute physiology and chronic health evaluation II (APACHE II) score, length of ICU and hospital stay, ICU and hospital mortality ( p <0.001, p =0.011, p <0.001, p =0.031, p =0.016). Candida score was significantly higher in candidemic patients (3.0 vs 0.0 p <0.001). Conclusion: Among fungal growths in samples from critically ill patients, the incidence of non- albicans Candida strains was gradually increasing. Older age, higher APACHE II score, and longer hospital and ICU stay were associated with fungal growths. Competing Interests: The authors declare no conflict of interest. (Copyright © 2024 Infectious Diseases and Clinical Microbiology.) |
| Databáze: | MEDLINE |
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