Illuminating the complete ß-cell mass of the human pancreas- signifying a new view on the islets of Langerhans.

Autor: Lehrstrand J; Department of Medical and Translational Biology, Umeå University, Umeå, Sweden., Davies WIL; Department of Medical and Translational Biology, Umeå University, Umeå, Sweden., Hahn M; Department of Medical and Translational Biology, Umeå University, Umeå, Sweden., Korsgren O; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Alanentalo T; Department of Medical and Translational Biology, Umeå University, Umeå, Sweden., Ahlgren U; Department of Medical and Translational Biology, Umeå University, Umeå, Sweden. Ulf.Ahlgren@umu.se.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Apr 18; Vol. 15 (1), pp. 3318. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1038/s41467-024-47686-7
Abstrakt: Pancreatic islets of Langerhans play a pivotal role in regulating blood glucose homeostasis, but critical information regarding their mass, distribution and composition is lacking within a whole organ context. Here, we apply a 3D imaging pipeline to generate a complete account of the insulin-producing islets throughout the human pancreas at a microscopic resolution and within a maintained spatial 3D context. These data show that human islets are far more heterogenous than previously accounted for with regards to their size distribution and cellular make up. By deep tissue 3D imaging, this in-depth study demonstrates that 50% of the human insulin-expressing islets are virtually devoid of glucagon-producing α-cells, an observation with significant implications for both experimental and clinical research.
(© 2024. The Author(s).)
Databáze: MEDLINE
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