Hydrangea serrata extract attenuates PM-exacerbated airway inflammation in the CARAS model by modulating the IL-33/ST2/NF-κB signaling pathway.

Autor: Jin J; Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea., Nguyen TV; Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea., Jiang Y; Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea., Yu ZN; Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea., Song CH; Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea; Institute for Medical Sciences, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea., Lee SY; Department of Food Biotechnology, University of Science and Technology (UST), Daejeon 34113, South Korea; Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, South Korea., Shin HS; Department of Food Biotechnology, University of Science and Technology (UST), Daejeon 34113, South Korea; Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, South Korea., Chai OH; Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea; Institute for Medical Sciences, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, South Korea. Electronic address: okchai1004@jbnu.ac.kr.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 May; Vol. 174, pp. 116596. Date of Electronic Publication: 2024 Apr 16.
DOI: 10.1016/j.biopha.2024.116596
Abstrakt: Particulate matter (PM) significantly contributes to the global health crisis of respiratory diseases. It is known to induce and exacerbate conditions such as asthma and respiratory infections. Long exposure to PM can increase the risk of combined allergic rhinitis and asthma syndrome (CARAS). Although therapeutic drugs can be used to improve symptoms of respiratory diseases caused by PM, their usage is often accompanied by side effects. Therefore, many studies are being conducted to discover functional food materials that can more effectively treat respiratory diseases while minimizing the side effects of these therapeutic drugs. This study was conducted to investigate the efficacy of Hydrangea serrata extract (HSE) in airway inflammation in a mouse model of CARAS exacerbated by PM. In the CARAS mouse model worsened by PM, the airway inflammation improvement effect of HSE was evaluated by analyzing allergic nasal symptoms, changes in inflammatory cells, OVA-specific immunoglobulin (Ig) levels, cytokines, mast cell activation, and histopathological findings of both nasal mucosa and lung tissue. HSE effectively reduced OVA-specific IgE and IgG1 and inhibited the production of T helper type 2 (Th2)-related cytokines such as IL-4 and IL-5. Importantly, HSE reduced IL-33 and ST2 expression and inhibited the activation of the NF-κB signaling pathway. In addition, HSE inhibited airway hypersensitivity, mucus production, and inflammatory cell infiltration. These results suggest that HSE may inhibit airway inflammation in CARAS/PM mice by regulating the IL-33/ST2/NF-κB signaling pathway, opening avenues for considering HSE as a potential material for treating allergic airway inflammation diseases in the future.
Competing Interests: Declaration of Competing Interest The authors affirm that this paper is free of any conflicts of interest.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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