Growth-Associated Protein 43 and Tensor-Based Morphometry Indices in Mild Cognitive Impairment.

Autor: Seyedmirzaei H; Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran., Salmannezhad A; Student Research Committee, Ghazvin University of Medical Sciences, Ghazvin, Iran., Ashayeri H; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Shushtari A; Faculty of Medicine , Mazandaran University of Medical Sciences, Sari, Iran. alishoushtari1377@gmail.com., Farazinia B; Faculty of Economics and Management, Shiraz Branch, Islamic Azad University, Shiraz, Iran., Heidari MM; Student Research Committee, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Momayezi A; School of Chemical engineering, Iran University of Science and Technology, Tehran, Iran., Shaki Baher S; Faculty of Medicine, Tehran Branch, Islamic Azad University, Tehran, Iran.
Jazyk: angličtina
Zdroj: Neuroinformatics [Neuroinformatics] 2024 Jul; Vol. 22 (3), pp. 239-250. Date of Electronic Publication: 2024 Apr 17.
DOI: 10.1007/s12021-024-09663-9
Abstrakt: Growth-associated protein 43 (GAP-43) is found in the axonal terminal of neurons in the limbic system, which is affected in people with Alzheimer's disease (AD). We assumed GAP-43 may contribute to AD progression and serve as a biomarker. So, in a two-year follow-up study, we assessed GAP-43 changes and whether they are correlated with tensor-based morphometry (TBM) findings in patients with mild cognitive impairment (MCI). We included MCI and cognitively normal (CN) people with available baseline and follow-up cerebrospinal fluid (CSF) GAP-43 and TBM findings from the ADNI database. We assessed the difference between the two groups and correlations in each group at each time point. CSF GAP-43 and TBM measures were similar in the two study groups in all time points, except for the accelerated anatomical region of interest (ROI) of CN subjects that were significantly greater than those of MCI. The only significant correlations with GAP-43 observed were those inverse correlations with accelerated and non-accelerated anatomical ROI in MCI subjects at baseline. Plus, all TBM metrics decreased significantly in all study groups during the follow-up in contrast to CSF GAP-43 levels. Our study revealed significant associations between CSF GAP-43 levels and TBM indices among people of the AD spectrum.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: