The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan., Ahmed HM; Department of Dental Industry Techniques, Al-Noor University College, Nineveh, Iraq., Alani ZK; College of Health and Medical Technical, Al-Bayan University, Baghdad, Iraq., Al Zuhairi RAH; National University of Science and Technology, Nasiriyah, Dhi Qar, Iraq., Almarhoon ZM; Department of Chemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia., Ahmad H; Section of Mathematics, International Telematic University Uninettuno, Corso Vittorio Emanuele II, 39, 00186, Rome, Italy. hijazahmad091@gmail.com.; Center for Applied Mathematics and Bioinformatics, Gulf University for Science and Technology, Mubarak Al-Abdullah, Kuwait. hijazahmad091@gmail.com.; Department of Computer Science and Mathematics, Lebanese American University, Beirut, Lebanon. hijazahmad091@gmail.com., Ubaid M; Medical Technical College, Al-Farahidi University, Baghdad, Iraq., Alwan NH; Department of Nursing, Al-Zahrawi University College, Karbala, Iraq.
Jazyk: angličtina
Zdroj: Neuromolecular medicine [Neuromolecular Med] 2024 Apr 17; Vol. 26 (1), pp. 14. Date of Electronic Publication: 2024 Apr 17.
DOI: 10.1007/s12017-024-08783-4
Abstrakt: Multiple sclerosis (MS) is a chronic condition affecting the central nervous system (CNS), where the interplay of genetic and environmental factors influences its pathophysiology, triggering immune responses and instigating inflammation. Contemporary research has been notably dedicated to investigating the contributions of gut microbiota and their metabolites in modulating inflammatory reactions within the CNS. Recent recognition of the gut microbiome and dietary patterns as environmental elements impacting MS development emphasizes the potential influence of small, ubiquitous molecules from microbiota, such as short-chain fatty acids (SCFAs). These molecules may serve as vital molecular signals or metabolic substances regulating host cellular metabolism in the intricate interplay between microbiota and the host. A current emphasis lies on optimizing the health-promoting attributes of colonic bacteria to mitigate urinary tract issues through dietary management. This review aims to spotlight recent investigations on the impact of SCFAs on immune cells pivotal in MS, the involvement of gut microbiota and SCFAs in MS development, and the considerable influence of probiotics on gastrointestinal disruptions in MS. Comprehending the gut-CNS connection holds promise for the development of innovative therapeutic approaches, particularly probiotic-based supplements, for managing MS.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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