Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway.
| Autor: | Ajibare AJ; Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Lead City University, Ibadan, Nigeria., Odetayo AF; Physiology Department, Federal University of Health Sciences, Ila-Orangun, Nigeria., Akintoye OO; Department of Physiology, Faculty of Basic Medical Science, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria., Olayaki LA; Department of Physiology, University of Ilorin, Ilorin, Nigeria. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Redox report : communications in free radical research [Redox Rep] 2024 Dec; Vol. 29 (1), pp. 2341537. Date of Electronic Publication: 2024 Apr 17. |
| DOI: | 10.1080/13510002.2024.2341537 |
| Abstrakt: | Background: Acrylamide is a toxic substance formed in some foods that require high-temperature cooking processes and has been implicated as a gonadotoxic agent. Zinc, on the other hand, is a known antioxidant with fertility-enhancing properties. Hence, this study was designed to explore the possible ameliorative effect of zinc in acrylamide-induced gonadotoxicity. Methods: Twenty-four male Wistar rats were randomized into control, acrylamide (10 mg/kg of acrylamide), acrylamide + 1 mg/kg of zinc, and acrylamide + 3 mg/kg of zinc. The administration was via the oral route and lasted for 56 days. Results: Zinc treatment ameliorated acrylamide-impaired sperm quality, normal testicular histoarchitecture, and hormonal balance, which was accompanied by increased testicular malondialdehyde and interleukin-1β and decreased testicular superoxide dismutase (SOD) and catalase (CAT). Furthermore, zinc prevented acrylamide-induced downregulation of testicular nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and B-cell lymphoma 2 (BCl2) expression and upregulation of testicular nuclear factor kappa B (NF-κB) and bcl-2-like protein 4 (bax) expression. Conclusion: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|