Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity.

Autor: Yen PH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Tai BH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.; Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam., Thuy Hang DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Doan Tung Lam L; Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam., Dung DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Trang DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Thi Hai Yen D; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Hoang NH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Thanh Huong PT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Dung NV; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Bang NA; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com., Duy ND; Center for High Technology Research and Development, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam., Van Kiem P; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.; Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2024 Apr 16; Vol. 14 (17), pp. 12147-12157. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
DOI: 10.1039/d4ra01483a
Abstrakt: In this study, seven new pentacyclic triterpene glycosides, named dendrocinaosides A-G (1-7), and six known ones (8-13) were isolated from the whole plants of Dendrobium officinale . Their structures were determined by analyses of HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-4, 8, and 9 potentially inhibited α-glucosidase and α-amylase activities with the IC 50 values ranging from 31.3 ± 2.2 to 42.4 ± 2.5 μM for anti α-glucosidase and from 36.5 ± 1.8 to 56.4 ± 2.0 μM for anti α-amylase activities, respectively, which were lower than that of the positive control, acarbose, showing IC 50 values of 47.1 ± 1.4 μM for anti α-glucosidase and 145.7 ± 2.2 μM for anti α-amylase.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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