Adolescents and young adults with cancer: the clinical course of COVID-19 infections.

Autor:	Wolfson JA; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA., Davis ES; Department of Surgery, Boston University/Boston Medical Center, Boston, MA, USA., Saha A; Pediatric Hematology-Oncology, Prisma Health Upstate, Bi-Lo Charities Children's Cancer Center, and Greenville Health System, Greenville, SC, USA., Martinez I; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA., McCall D; Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA., Kothari P; Pediatric Hematology-Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Brackett J; Pediatric Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital, Houston, TX, USA., Dickens DS; Pediatric Hematology-Oncology, Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Kahn AR; Pediatric Hematology/Oncology, Department of Pediatrics, St Joseph's University Medical Center, Paterson, NJ, USA., Schwalm C; Pediatric Hematology-Oncology, Department of Pediatrics, Bronson Methodist Hospital, Kalamazoo, MI, USA., Sharma A; Pediatric Hematology-Oncology, Department of Pediatrics, Rutgers Cancer Institute, New Brunswick, NJ, USA., Richman J; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA., Cuglievan B; Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA., Bhatia S; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA., Dai C; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA., Levine JM; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA., Johnston EE; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Aug 01; Vol. 116 (8), pp. 1366-1373.
DOI:	10.1093/jnci/djae085
Abstrakt:	Adolescents and young adults (ie, individuals aged 15-39 years, known as AYAs) with cancer face unique vulnerabilities yet remain underrepresented in clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8%-12%). We used the Pediatric Oncology COVID-19 Case Report to examine the clinical course of COVID-19 among AYAs with cancer. The Pediatric Oncology COVID-19 Case Report collects deidentified clinical and sociodemographic data regarding individuals aged from birth to 39 years with cancer (37%) and COVID-19 from more than 100 institutions. Between April 1, 2020, and November 28, 2023, 191 older AYAs (individuals 22-39 years of age) and 640 younger AYAs (individuals 15-21 years of age) were captured. Older AYAs were less often hospitalized (P < .001), admitted to the intensive care unit (P = .02), and required respiratory support (P = .057). In multivariable analyses, older AYAs faced 80% lower odds of intensive care unit admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of intensive care unit admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform oncology teams directing COVID-19 management and prevention in AYA patients with cancer. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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