Dedifferentiated liposarcoma of the spermatic cord.
| Autor: | Panther EJ; Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA ericpanther@ufl.edu., Lyons H; Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA., Shychuk AJ; Internal Medicine, University of Florida, Gainesville, Florida, USA.; Internal Medicine, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2024 Apr 16; Vol. 17 (4). Date of Electronic Publication: 2024 Apr 16. |
| DOI: | 10.1136/bcr-2023-258954 |
| Abstrakt: | A man in his 60s presented to an outside hospital with persistent groin pain and a scrotal mass which was thought to be a recurrent hernia. Three months after initial presentation, the patient was found to have dedifferentiated liposarcoma (LPS) of the spermatic cord. LPS of the spermatic cord is a rare entity; however, clinicians should have LPS on the differential diagnosis especially in men with recurrent scrotal pain and mass. If unrecognised, LPS is associated with a high degree of morbidity and mortality. LPS can be subdivided into well-differentiated LPS, dedifferentiated LPS, myxoid LPS and pleomorphic LPS. In patients with advanced or metastatic LPS, chemotherapy consisting of Adriamycin, ifosfamide and mesna is used despite LPS being relatively chemoresistant. Therapies inhibiting mouse double minute 2 homologue, an oncoprotein that is a negative regulator of the tumour suppressor p53, appear to be promising in preclinical trials. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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