The beneficial impacts of nano-propolis liposomes as an anti-stressor agent on broiler chickens kept under cyclic heat stress.

Autor:	Eldiasty JG; Biology Department, University College of Haqel, University of Tabuk, Tabuk, Saudi Arabia. Electronic address: galdiasti@ut.edu.sa., Al-Sayed HMA; Department of Food and Nutrition Science, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabi; Department of Food Science, Faculty of Agricultural, University of Ain Shams, Cairo, Egypt., Farsi RM; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Algothmi KM; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Immunology unit KFMC, King Abdulaziz University, Kingdom of Saudi Arabia., Alatawi FS; Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk 71421, Saudi Arabia., AlGhabban AJ; Biology Department, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia., Alnawwar WH; Faculty of Medicine, University of Tabuk, Tabuk 71421, Saudi Arabia., Alatawi AO; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71421, Saudi Arabia., Hamdy HM; Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Helwan, Egypt.
Jazyk:	angličtina
Zdroj:	Poultry science [Poult Sci] 2024 Jun; Vol. 103 (6), pp. 103695. Date of Electronic Publication: 2024 Mar 28.
DOI:	10.1016/j.psj.2024.103695
Abstrakt:	This research assessed the impacts of dietary nano-propolis liposomes (NPRL) inclusion on the growth, blood biochemical components, immune function, and oxidative status of broilers exposed to cyclic heat stress (HS). Birds were fed with a basal diet supplemented with various levels of NPRL at 0 (HS), 100 (NPRL100), 250 (NPRL250) and 400 (NPRL400) mg/kg diets. Diets supplemented with NPRL significantly improved the growth indices and feed utilization, hemoglobin and red blood cells (P < 0.01). White blood cells, lymphocytes and monocytes were significantly decreased by NPRL inclusion (P < 0.001). Dietary supplementation of 250 or 400 mg of NPRL /kg reduced the pathogenic bacteria counts (Salmonella, E. coli and Enterococci) (P < 0.01). The birds fed diets with NPRL (400 mg/kg diet) significantly downregulated the mRNA IFNγ gene (p < 0.001), while both groups (NPRL100 and NPRL250) had similar results (P > 0.05). The iNOS gene was significantly decreased by the dietary NPRL inclusion in a dose-dependent manner. Birds in NRPL groups had inferior levels of the mRNA of interleukin-4 and tumor necrosis factor genes. The lysosome activity was significantly reduced by dietary 250 or 400 mg of NPRL inclusion (P < 0.001). Birds in NPRL250 and NPRL100 had greater IgG (P < 0.05) than the other groups. Regarding oxidative-related biomarkers, dietary NPRL inclusion decreased myeloperoxidase and malondialdehyde levels significantly compared to those with the HS group (P < 0.001). Broilers in the NPRL400 group had the lowest levels of total bilirubin and gamma-glutamyl transferase. NPRL250 had the lowest values of urea compared with other groups (P < 0.001). Dietary NPRL inclusion improved the broiler's hepatic and intestinal architecture exposed to cyclic heat stress. These results indicate that employing NPRL in the diets of stressed broilers can enhance heat resistance by enhancing blood metabolites and immunity, reducing inflammation and oxidative stress. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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