The capacity of cognitive tests to detect generalized anxiety disorder (GAD): A pilot study.

Autor: Baussay A; Université de Versailles Saint-Quentin-en-Yvelines. 2 Av. de La Source de La Bièvre, 78180, Montigny-le-Bretonneux, France., Di Lodovico L; CMME, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, 100 Rue de La Santé, F-75014, Paris, France; Université Paris Cité, INSERM, UMR1266, F-75013, Paris, France., Poupon D; CMME, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, 100 Rue de La Santé, F-75014, Paris, France., Doublet M; Psydatalab Platform, 7 Rue de La Rosiere, 75015, Paris, France., Ramoz N; Université Paris Cité, INSERM, UMR1266, F-75013, Paris, France., Duriez P; CMME, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, 100 Rue de La Santé, F-75014, Paris, France; Université Paris Cité, INSERM, UMR1266, F-75013, Paris, France., Gorwood P; CMME, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, 100 Rue de La Santé, F-75014, Paris, France; Université Paris Cité, INSERM, UMR1266, F-75013, Paris, France. Electronic address: p.gorwood@ghu-paris.fr.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2024 Jun; Vol. 174, pp. 94-100. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1016/j.jpsychires.2024.04.006
Abstrakt: Cognitive impairment remains understudied in generalized anxiety disorder (GAD), despite the high prevalence and substantial burden associated with this disorder. We aimed to assess cognitive impairment in patients with GAD and evaluate the ability of cognitive tests to detect this disorder. Because of its high rate of comorbidity, we also examined how other anxiety disorders and current major depressive episodes affected our results. We tested 263 consecutive general practice outpatients. We used the GAD-7 and the Mini International Neuropsychiatric Interview (MINI) to detect anxiety and mood disorders. We assessed cognitive performance with the Stroop test, a facial emotion recognition test, and the trail-making test (TMT). Compared to patients without GAD, patients with GAD were significantly slower to complete the TMT (B-A) and faster to recognize emotions, especially negative ones such as disgust and anger. When controlling for other anxiety disorders and current major depressive episode, GAD retained a significant effect on the TMT (B-A) , but not on the emotion recognition test. The TMT (B-A) could detect GAD with good accuracy (area under the curve (AUC) = 0.83, maximal Youden's index = 0.56), which was by no means comparable to the GAD-7 (AUC = 0.97, Youden's index = 0.81). While it is not efficient enough to replace the GAD-7 as a diagnostic tool, the capacity of the TMT (B-A) to detect GAD emphasizes the importance of cognitive flexibility impairment in GAD.
Competing Interests: Declaration of competing interest Philip Gorwood received during the last 5 years fees for presentations at congresses or participation in scientific boards from Angelini, EISI, Janssen, Lundbeck, Otsuka, Richter and Merck. Other authors declare no conflict of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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