Associations of Serum Perfluoroalkyl Substances and Placental Human Chorionic Gonadotropin in Early Pregnancy, Measured in the UPSIDE Study in Rochester, New York.

Autor: Liang HW; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA., Koistinen H; Department of Clinical Chemistry and Haematology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Barrett ES; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA.; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York, USA., Xun X; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA., Yin Q; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA., Kannan K; Department of Pediatrics, New York University, New York, USA.; Department of Environmental Medicine, New York University, New York, USA., Moog NK; Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany., Ng C; Department of Civil and Environmental Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., O'Connor TG; Department of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA., Miller R; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York, USA., Adibi JJ; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Environmental health perspectives [Environ Health Perspect] 2024 Apr; Vol. 132 (4), pp. 47008. Date of Electronic Publication: 2024 Apr 16.
DOI: 10.1289/EHP12950
Abstrakt: Background: Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant women and associated with adverse outcomes related to impaired placental function. Human chorionic gonadotropin (hCG) is a dimeric glycoprotein hormone that can indicate placental toxicity.
Objectives: Our aim was to quantify the association of serum PFAS with placental hCG, measured as an intact molecule (hCG), as free alpha-( hCG α ) and beta-subunits ( hCG β ), and as a hyperglycosylated form (h-hCG), and evaluate effect measure modification by social determinants and by fetal sex.
Methods: Data were collected from 326 pregnant women enrolled from 2015 to 2019 in the UPSIDE study in Rochester, New York. hCG forms were normalized for gestational age at the time of blood draw in the first trimester [multiple of the median (MoM)]. Seven PFAS were measured in second-trimester maternal serum. Multivariate imputation by chained equations and inverse probability weighting were used to evaluate robustness of linear associations. PFAS mixture effects were estimated by Bayesian kernel machine regression.
Results: Perfluorohexane sulfonic acid (PFHxS) [ hCG β : 0.29 log MoM units per log PFHxS; 95% confidence interval (CI): 0.08, 0.51] and perfluorodecanoic acid (PFDA) (hCG: - 0.09 ; 95% CI: - 0.16 , - 0.02 ) were associated with hCG in the single chemical and mixture analyses. The PFAS mixture was negatively associated with hCG α and positively with hCG β . Subgroup analyses revealed that PFAS associations with hCG differed by maternal race/ethnicity and education. Perfluoropentanoic acid (PFPeA) was associated with hCG β only in Black participants ( - 0.23 ; 95% CI: - 0.37 , - 0.09 ) and in participants with high school education or less ( - 0.14 ; 95% CI: - 0.26 , - 0.02 ); conversely, perfluorononanoic acid (PFNA) was negatively associated with hCG α only in White participants ( - 0.15 ; 95% CI: - 0.27 , - 0.03 ) and with hCG β only in participants with a college education or greater ( - 0.19 ; 95% CI: - 0.36 , - 0.01 ). These findings were robust to testing for selection bias, confounding bias, and left truncation bias where PFAS detection frequency was < 100 % . Two associations were negative in male (and null in female) pregnancies: Perfluoroundecanoic acid (PFUnDA) with hCG α , and PFNA with h-hCG.
Conclusions: Evidence was strongest for the association between PFHxS and PFDA with hCG in all participants and for PFPeA and PFNA within subgroups defined by social determinants and fetal sex. PFAS mixture associations with hCG α and hCG β differed, suggesting subunit-specific types of toxicity and/or regulation. Future studies will evaluate the biological, clinical and public health significance of these findings. https://doi.org/10.1289/EHP12950.
Databáze: MEDLINE
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