Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights.

Autor:	Soleimani A; Department of Biochemistry, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Saeedi N; Medical School, Islamic Azad University, Mashhad, Iran., Al-Asady AM; Department of Pharmacology, University of Warith Al-Anbiyaa, Karbala, Iraq., Nazari E; Department of Physiology, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Hanaie R; Department of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Khazaei M; Department of Physiology, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Ghorbani E; Department of Microbiology, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Akbarzade H; Department of Biochemistry, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Ryzhikov M; Department of Biochemistry, Saint Louis University, St. Louis, MO 63103, USA., Avan A; Department of Genetics, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran., Mehr SMH; Department of Biochemistry, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2024; Vol. 30 (18), pp. 1386-1397.
DOI:	10.2174/0113816128291321240329050945
Abstrakt:	Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markers cancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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