Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials.
| Autor: | Austin PD; Department of Palliative Care, HammondCare, Greenwich Hospital, Sydney, New South Wales, Australia., Lee W; Department of Palliative Care, HammondCare, Greenwich Hospital, Sydney, New South Wales, Australia.; Improving Care for Palliative Aged, and Chronic Care through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Costa DS; Sydney Medical School-Northern, University of Sydney, Sydney, New South Wales, Australia.; Kolling Institute, Northern Sydney Local Health District, Sydney, NSW, Australia.; School of Psychology, University of Sydney, Sydney, NSW, Australia.; The University of Sydney, Sydney, NSW, Australia., Ritchie A; Department of Palliative Care, HammondCare, Greenwich Hospital, Sydney, New South Wales, Australia., Lovell MR; Department of Palliative Care, HammondCare, Greenwich Hospital, Sydney, New South Wales, Australia.; Sydney Medical School-Northern, University of Sydney, Sydney, New South Wales, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2024 Apr 06; Vol. 10 (7), pp. e29193. Date of Electronic Publication: 2024 Apr 06 (Print Publication: 2024). |
| DOI: | 10.1016/j.heliyon.2024.e29193 |
| Abstrakt: | Purpose: To evaluate effects of aerobic and resistance exercises for cancer-related pain in adults with and surviving cancer. Secondary objectives were to a) evaluate the effect of exercise on fatigue, psychological function, physical function, b) assess fidelity to exercise. Design: A systematic search of MEDLINE, EMBASE, AMED, CINAHL and Cochrane Central Register of Controlled Trials was conducted to identify randomised controlled trials (RCTs) comparing aerobic and/or resistance exercise to control groups. The primary endpoint were changes in cancer-related pain intensity from baseline to post intervention. Meta-regression analysis evaluated predictors for heterogeneity between study findings. Tolerability was defined as reporting of exercise-induced adverse events while fidelity evaluated by reported intervention dropout. Results: Twenty-three RCTs including 1954 patients (age 58 ± 8.5 years; 78 % women); 1087 (56 %) and 867 (44 %) allocated to aerobic/resistance exercise therapy and control group, respectively. Exercise therapy was associated with small to moderate decreases in cancer-related pain compared to controls (SMD = 0.38, 95 % CI: 0.17, 0.58). Although there was significant heterogeneity between individual and pooled study effects ( Q = 205.25, p < 0.0001), there was no publication bias. Meta-regression including supervision, age, duration and exercise type as moderators showed no significant differences in reported outcomes. Analysis of secondary outcomes revealed a moderate effect for improvements in physical function, fatigue and psychological symptoms. Conclusions: Aerobic and resistance exercises are tolerable and effective adjunct therapies to reduce cancer-related pain while also improving physical function, fatigue and mood. Future RCTs of dose, frequency, compliance and exercise type in specific cancer settings are required. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Philip Austin reports financial support, article publishing charges, and statistical analysis were provided by The Taylor Foundation. Philip Austin reports a relationship with The Taylor Foundation that includes: funding grants, non-financial support, and speaking and lecture fees. I have no competing interests to declare If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors. Published by Elsevier Ltd.) |
| Databáze: | MEDLINE |
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