MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.

Autor:	Blokland GAM; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Netherlands.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States., Maleki N; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Jovicich J; Center for Mind/Brain Sciences (CIMeC), University of Trento, Trento, Italy., Mesholam-Gately RI; Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., DeLisi LE; Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States., Turner JA; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, United States., Shenton ME; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, MA, United States., Voineskos AN; Kimel Family Translational Imaging Genetics Laboratory, Department of Psychiatry, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Kahn RS; Brain Centre Rudolf Magnus, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands., Roffman JL; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Holt DJ; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Ehrlich S; Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Kikinis Z; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States., Dazzan P; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Murray RM; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Lee J; Institute of Mental Health, Woodbridge Hospital, Singapore., Sim K; Institute of Mental Health, Woodbridge Hospital, Singapore., Lam M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Analytical & Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States.; Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.; Institute of Mental Health, Woodbridge Hospital, Singapore., de Zwarte SMC; Brain Centre Rudolf Magnus, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands., Walton E; Department of Psychology, University of Bath, Bath, United Kingdom., Kelly S; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.; Laboratory of NeuroImaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Picchioni MM; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Bramon E; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom.; Mental Health Neuroscience Research Department, UCL Division of Psychiatry, University College London, United Kingdom., Makris N; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.; Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.; Department of Neurology, Harvard Medical School, Boston, MA, United States., David AS; Division of Psychiatry, University College London, London, United Kingdom., Mondelli V; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Reinders AATS; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Oykhman E; Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, United States., Morris DW; Cognitive Genetics and Cognitive Therapy Group, Neuroimaging and Cognitive Genomics (NICOG) Centre and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland., Gill M; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland., Corvin AP; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland., Cahn W; Brain Centre Rudolf Magnus, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands., Ho N; Institute of Mental Health, Woodbridge Hospital, Singapore., Liu J; Genome Institute, Singapore., Gollub RL; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Manoach DS; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, United States., Sponheim SR; Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States., Buka SL; Department of Epidemiology, Brown University, Providence, RI, United States., Cherkerzian S; Department of Medicine, Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Thermenos HW; Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Dickie EW; Kimel Family Translational Imaging Genetics Laboratory, Department of Psychiatry, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Ciufolini S; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Reis Marques T; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Crossley NA; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom., Purcell SM; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Division of Psychiatric Genomics, Departments of Psychiatry and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States., van Haren NEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands.; Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands., Toulopoulou T; Department of Psychology & National Magnetic Resonance Research Center (UMRAM), Aysel Sabuncu Brain Research Centre (ASBAM), Bilkent University, Ankara, Turkey.; Department of Psychiatry, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Donohoe G; Cognitive Genetics and Cognitive Therapy Group, Neuroimaging and Cognitive Genomics (NICOG) Centre and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland.; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland., Goldstein JM; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Medicine, Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States., Keshavan MS; Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; University of Pittsburgh Medical Center, Pittsburgh, PA, United States.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Petryshen TL; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States., Del Re EC; Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, MA, United States.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Jazyk:	angličtina
Zdroj:	International journal of clinical and health psychology : IJCHP [Int J Clin Health Psychol] 2024 Apr-Jun; Vol. 24 (2), pp. 100458. Date of Electronic Publication: 2024 Apr 09.
DOI:	10.1016/j.ijchp.2024.100458
Abstrakt:	Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with global functioning decreasing with increased LV volume. This study investigates the relationship between LV volume, CC abnormalities, and the microRNA MIR137 and its regulated genes in SZ, because of MIR137's essential role in neurodevelopment. Methods . Participants were 1224 SZ probands and 1466 unaffected controls from the GENUS Consortium. Brain MRI scans, genotype, and clinical data were harmonized across cohorts and employed in the analyses. Results. Increased LV volumes and decreased CC central, mid-anterior, and mid-posterior volumes were observed in SZ probands. The MIR137-regulated ephrin pathway was significantly associated with CC:LV ratio, explaining a significant proportion (3.42 %) of CC:LV variance, and more than for LV and CC separately. Other pathways explained variance in either CC or LV, but not both. CC:LV ratio was also positively correlated with Global Assessment of Functioning, supporting previous subsample findings. SNP-based heritability estimates were higher for CC central:LV ratio (0.79) compared to CC or LV separately. Discussion. Our results indicate that the CC:LV ratio is highly heritable, influenced in part by variation in the MIR137-regulated ephrin pathway. Findings suggest that the CC:LV ratio may be a risk indicator in SZ that correlates with global functioning. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The author is an Editorial Board Member/Editor-in-Chief/Associate Editor/Guest Editor for International Journal of Clinical and Health Psychology and was not involved in the editorial review or the decision to publish this article. (© 2024 The Author(s).)
Databáze:	MEDLINE
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