Human skeletal muscle aging atlas.

Autor: Kedlian VR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Wang Y; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Liu T; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Chen X; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Tudor C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Shen Z; Department of Thoracic Surgery, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China., Fasouli ES; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Prigmore E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kleshchevnikov V; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Pett JP; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Li T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Lawrence JEG; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Perera S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Prete M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Huang N; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Guo Q; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Zeng X; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Yang L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Polański K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Chipampe NJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Dabrowska M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Li X; Core Facilities for Medical Science, Sun Yat-sen University, Guangzhou, China., Bayraktar OA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Patel M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kumasaka N; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK.; Collaborative Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Xiang AP; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK. ks10014@cam.ac.uk.; Collaborative Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK. ks10014@cam.ac.uk., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. st9@sanger.ac.uk.; Cavendish Laboratory, University of Cambridge, Cambridge, UK. st9@sanger.ac.uk., Zhang H; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. zhanghongbo@mail.sysu.edu.cn.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. zhanghongbo@mail.sysu.edu.cn.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2024 May; Vol. 4 (5), pp. 727-744. Date of Electronic Publication: 2024 Apr 15.
DOI: 10.1038/s43587-024-00613-3
Abstrakt: Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes. Our atlas also highlights an expansion of nuclei associated with the neuromuscular junction, which may reflect re-innervation, and outlines how the loss of fast-twitch myofibers is mitigated through regeneration and upregulation of fast-type markers in slow-twitch myofibers with age. Furthermore, we document the function of aging muscle microenvironment in immune cell attraction. Overall, we present a comprehensive human skeletal muscle aging resource ( https://www.muscleageingcellatlas.org/ ) together with an in-house mouse muscle atlas to study common features of muscle aging across species.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: