LSD increases sleep duration the night after microdosing.

Autor: Allen N; Faculty of Engineering, University of Auckland, Auckland, 1010, New Zealand. nathan.allen@auckland.ac.nz., Jeremiah A; Faculty of Engineering, University of Auckland, Auckland, 1010, New Zealand., Murphy R; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand., Sumner R; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand., Forsyth A; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand., Hoeh N; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand., Menkes DB; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand., Evans W; Mana Health, 7 Ruskin St, Parnell, Auckland, 1052, New Zealand., Muthukumaraswamy S; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand., Sundram F; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand., Roop P; Faculty of Engineering, University of Auckland, Auckland, 1010, New Zealand.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Apr 15; Vol. 14 (1), pp. 191. Date of Electronic Publication: 2024 Apr 15.
DOI: 10.1038/s41398-024-02900-4
Abstrakt: Microdosing psychedelic drugs at a level below the threshold to induce hallucinations is an increasingly common lifestyle practice. However, the effects of microdosing on sleep have not been previously reported. Here, we report results from a Phase 1 randomized controlled trial in which 80 healthy adult male volunteers received a 6-week course of either LSD (10 µg) or placebo with doses self-administered every third day. Participants used a commercially available sleep/activity tracker for the duration of the trial. Data from 3231 nights of sleep showed that on the night after microdosing, participants in the LSD group slept an extra 24.3 min per night (95% Confidence Interval 10.3-38.3 min) compared to placebo-with no reductions of sleep observed on the dosing day itself. There were no changes in the proportion of time spent in various sleep stages or in participant physical activity. These results show a clear modification of the physiological sleep requirements in healthy male volunteers who microdose LSD. The clear, clinically significant changes in objective measurements of sleep observed are difficult to explain as a placebo effect. Trial registration: Australian New Zealand Clinical Trials Registry: A randomized, double-blind, placebo-controlled trial of repeated microdoses of lysergic acid diethylamide (LSD) in healthy volunteers; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381476 ; ACTRN12621000436875.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: