The diagnostic difficulties of juvenile vulvar pemphigoid.

Autor: Gart S; College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA., Swali R; Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA., Lee EB; Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA., Harter N; Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.; Division of Pediatric Dermatology, Children's Nebraska, Omaha, Nebraska, USA.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2024 Sep-Oct; Vol. 41 (5), pp. 897-899. Date of Electronic Publication: 2024 Apr 15.
DOI: 10.1111/pde.15622
Abstrakt: Mucous membrane pemphigoid is a rare autoimmune disease affecting mucosal surfaces. Pediatric cases are exceptionally rare, one subtype being vulvar pemphigoid. Juvenile vulvar pemphigoid can be challenging to diagnose due to its rarity and subtle initial symptoms. We present a case of an 8-year-old girl successfully diagnosed early in the disease course via histopathology, and immunofluorescence. Detecting MMP can be complex due to variations in epitope binding typically not included in commercial ELISA assays, necessitating comprehensive workup. Missed diagnosis may lead to progression to systemic involvement with severe consequences; thus, timely diagnosis and treatment are crucial.
(© 2024 The Authors. Pediatric Dermatology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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