A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil.

Autor: Lima-Silva ML; Fundação Oswaldo Cruz, Instituto René Rachou, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil; Fundação Oswaldo Cruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil; Fundação Oswaldo Cruz, Instituto René Rachou, Programa de Pós-Graduação em Saúde Coletiva, Belo Horizonte, MG, Brazil. Electronic address: maria.esilva@fiocruz.br., Torres KCL; Fundação Oswaldo Cruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil; Universidade Edson Antônio Velano - UNIFENAS/MG, Brazil. Electronic address: karen.torres@fiocruz.br., Mambrini JVM; Fundação Oswaldo Cruz, Instituto René Rachou, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil; Fundação Oswaldo Cruz, Instituto René Rachou, Programa de Pós-Graduação em Saúde Coletiva, Belo Horizonte, MG, Brazil., Brot NC; Fundação Oswaldo Cruz, Instituto René Rachou, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil; Fundação Oswaldo Cruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil., Santos SO; Fundação Oswaldo Cruz, Instituto René Rachou, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil., Martins-Filho OA; Fundação Oswaldo Cruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil; Universidade do Estado do Amazonas - UEA, Brazil., Teixeira-Carvalho A; Fundação Oswaldo Cruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil; Universidade do Estado do Amazonas - UEA, Brazil., Lima-Costa MF; Fundação Oswaldo Cruz, Instituto René Rachou, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil., Peixoto SV; Fundação Oswaldo Cruz, Instituto René Rachou, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais, Escola de Enfermagem, Departamento de Gestão em Saúde, Belo Horizonte, MG, Brazil. Electronic address: sergio.peixoto@fiocruz.br.
Jazyk: angličtina
Zdroj: Experimental gerontology [Exp Gerontol] 2024 Jun 15; Vol. 191, pp. 112433. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1016/j.exger.2024.112433
Abstrakt: Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effort. The object of the study is to describe for the first time that the distribution of cytokines, chemokines, and growth factors serum levels, assessed by Luminex platform, has been examined in a Brazilian population-based study of older adult females and males by age. Blood samples from 2111 participants (≥50 years old) were analyzed at the baseline (2015/2016) of the ELSI-Brazil study. The exploratory variables considered in the study were age, sex, educational level, residence area, geographic region, alcohol and smoking consumption, physical activity, and self-reported medical diagnoses of hypertension, diabetes, asthma, arthritis, and cancer. The association between serum biomarker levels and age was assessed by a quantile regression model adjusted in the total population and stratified by sex. The significance level considered in the analysis was 0.05. The mean age of the participants was 62.9 years, with a slight majority of female (52.7 %). Differences were found between the sexes in the median circulating levels of the CCL11, CXCL10, and FGF biomarkers. Eight biomarkers showed significant associations with age, including the pro-inflammatory CXCL10, TNF-α, IL-6, IL-17, and IL-2; and type 2/regulatory CCL11 and IL-4, showing positive associations, and anti-inflammatory IL-1Ra showing a negative association. The results suggest similar associations between the sexes, revealing an inflammatory profile characterized by types 1 and 2. Remarkably, these findings reinforce the concept of the Inflammaging process in Brazilian population. These findings add novel insights to about the immunosenescence aspects in middle-income countries and help define biomarkers capable of monitoring inflammation in older adults.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest and none of financial or personal interests appeared to influence the work reported in this article.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: