Clinical features, coagulation and inflammatory biomarkers associated with poor in-hospital outcomes in a Honduran population with RT-PCR confirmed COVID-19.

Autor:	Aguilar-Andino D; Departamento de Epidemiologia, Hospital General Dr. Mario Catarino Rivas, San Pedro Sula, Honduras.; Departamento de Medicina, Universidad Nacional Autónoma de Honduras, San Pedro Sula, Honduras., Umaña AN; Facultad de Medicina y Cirugía, Universidad Católica de Honduras, Campus San Pedro y San Pablo, Honduras., Alas-Pineda C; Departamento de Epidemiologia, Hospital General Dr. Mario Catarino Rivas, San Pedro Sula, Honduras.; Facultad de Medicina y Cirugía, Universidad Católica de Honduras, Campus San Pedro y San Pablo, Honduras., Santos FM; Departamento de Medicina Interna, Hospital General Dr. Mario Catarino Rivas, San Pedro Sula, Honduras., Gómez AC; Departamento de Medicina Interna, Hospital General Dr. Mario Catarino Rivas, San Pedro Sula, Honduras., Soto MM; Departamento de Medicina Interna, Hospital General Dr. Mario Catarino Rivas, San Pedro Sula, Honduras., Osorio AL; Departamento de Medicina Interna, Hospital General Dr. Mario Catarino Rivas, San Pedro Sula, Honduras.
Jazyk:	angličtina
Zdroj:	Thrombosis update [Thromb Update] 2022 Dec; Vol. 9, pp. 100124. Date of Electronic Publication: 2022 Oct 04.
DOI:	10.1016/j.tru.2022.100124
Abstrakt:	Background: SARS-COV-2, in most cases, only generates a mild acute respiratory disease. However, patients with severe disease show an exaggerated response of the immune system, creating a pro-inflammatory state, which could cause abnormalities in the coagulation system that increases mortality. Latin American countries, specially those with limited resources, have few studies about clinical features, coagulation and inflammatory biomarkers that could be useful at admission to assess poor outcomes. Objective: The objective of this study is to describe the clinical features, coagulation, and inflammatory biomarkers, and identify risk factors at admission that are associated poor outcomes in Honduran population. Methods: A cohort study was conducted. 210 patients were included, which 105 died during hospitalization due to COVID-19 and 105 were discharged alive, between September 2020 and January 2021. Clinical and laboratorial data was retrospectively collected. Results: 57,6% of the population were male. The median age was 58 years. The median time between symptom onset and hospital admission was 6 days. D-dimer median was higher in the dead group compared with the alive group. Poor prognosis factors in the Cox multivariable model were male gender, age, symptom's duration, obesity and an elevated d dimer at admission. Conclusion: In low-middle income countries, the assessment of these clinical and laboratory tools, especially in those with risk factors for prothrombotic states, could help clinicians to correctly stratify disease prognosis, establish a baseline to evaluate further evolution, and also predict outcomes, thus improving patient management. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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