Sinonasal Adenocarcinoma: Clinicopathological Characterization and Prognostic Factors.

Autor:	Baptista Freitas M; Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT., Costa M; Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT., Freire Coelho A; Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT., Rodrigues Pereira P; Pathology, Centro Hospitalar Universitário de São João, Porto, PRT., Leal M; Otolaryngology - Head and Neck Surgery, Centro Hospitalar Universitário de São João, Porto, PRT., Sarmento C; Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT., Águas L; Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT., Barbosa M; Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Mar 13; Vol. 16 (3), pp. e56067. Date of Electronic Publication: 2024 Mar 13 (Print Publication: 2024).
DOI:	10.7759/cureus.56067
Abstrakt:	Sinonasal (SN) malignancies are rare. Within SN adenocarcinomas, the most frequent are intestinal-type adenocarcinomas (ITACs). ITAC has been associated with wood and leather dust occupational exposure and TP53 mutations. Not much information is available regarding its characterization and treatment. The aim of this study is to characterize the clinicopathologic and prognostic factors of patients with sinonasal adenocarcinomas (SNACs) treated in our tertiary-level hospital. A retrospective, consecutive study including SNAC patients diagnosed between 2004-2023 was conducted. Clinicopathological data was collected, and p53 status was assessed in the tumor specimens. The association between p53 status and clinicopathological variables, as well as their impact on survival, was evaluated. In total, 35 were included, most of them having ITAC (91.4%) with papillary subtype (37.5%); the majority were subjected to occupational risk exposure (82.9%). Overexpression of p53 was identified in 48.6% of the tumors. Papillary and colonic subtypes were associated with higher median progression-free survival (mPFS) than mucinous and solid subtypes (mPFS 37 months, 95% CI, 20.0-54.0, vs. 9 months, 95% CI, 7.15-10.85, p=0.01); the former was also associated with higher median overall survival (mOS) (mOS 64 months, 95% CI, 37.18-90.81 vs. 14 months, 95% CI, 0-41.58, p=0.02). Histologic grade 1-2 and macroscopic complete resection were associated with higher PFS (PFS of five months of 90.9% vs. 33.3%, p=0.01; mPFS of 37 months, 95% CI, 4.93-69.07 vs. 10 months, 95% CI, 6.43-13.57, p=0.04, respectively). Disease recurrence with distant metastases was associated with lower OS (11 months, 95% CI, 6.1-15.9 vs. 53 months, 95% CI, 22.70-83.30, p=0.04). This study reinforces the importance of protective occupational measures. Future studies will be important to validate the best treatment strategy in the advanced stages of this disease and also to identify new prognostic and/or therapeutic target biomarkers in SNAC. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Baptista Freitas et al.)
Databáze:	MEDLINE
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