The role of lipoylation in mitochondrial adaptation to methionine restriction.

Autor: Xue J; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China., Ye C; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.; Hainan Institute, Zhejiang University, Sanya, China.; National R&D Center for Freshwater Fish Processing, Jiangxi Normal University, Nanchang, China.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Jun; Vol. 46 (6), pp. e2300218. Date of Electronic Publication: 2024 Apr 14.
DOI: 10.1002/bies.202300218
Abstrakt: Dietary methionine restriction (MR) is associated with a spectrum of health-promoting benefits. Being conducive to prevention of chronic diseases and extension of life span, MR can activate integrated responses at metabolic, transcriptional, and physiological levels. However, how the mitochondria of MR influence metabolic phenotypes remains elusive. Here, we provide a summary of cellular functions of methionine metabolism and an overview of the current understanding of effector mechanisms of MR, with a focus on the aspect of mitochondria-mediated responses. We propose that mitochondria can sense and respond to MR through a modulatory role of lipoylation, a mitochondrial protein modification sensitized by MR.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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