Enzymatic biosynthesis of D-galactose derivatives: Advances and perspectives.

Autor: Liu J; College of Life Sciences, Yantai University, Yantai 264005, Shandong, China., Feng X; College of Life Sciences, Yantai University, Yantai 264005, Shandong, China; Yantai Key Laboratory of Characteristic Agricultural Biological Resources Conservation and Germplasm Innovation Utilization, Yantai University, Yantai 264005, Shandong, China., Liang L; College of Life Sciences, Yantai University, Yantai 264005, Shandong, China., Sun L; College of Life Sciences, Yantai University, Yantai 264005, Shandong, China; Yantai Key Laboratory of Characteristic Agricultural Biological Resources Conservation and Germplasm Innovation Utilization, Yantai University, Yantai 264005, Shandong, China. Electronic address: sliqin2005@163.com., Meng D; College of Life Sciences, Yantai University, Yantai 264005, Shandong, China; Yantai Key Laboratory of Characteristic Agricultural Biological Resources Conservation and Germplasm Innovation Utilization, Yantai University, Yantai 264005, Shandong, China. Electronic address: mengdd@ytu.edu.cn.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 267 (Pt 2), pp. 131518. Date of Electronic Publication: 2024 Apr 13.
DOI: 10.1016/j.ijbiomac.2024.131518
Abstrakt: D-Galactose derivatives, including galactosyl-conjugates and galactose-upgrading compounds, provide various physiological benefits and find applications in industries such as food, cosmetics, feed, pharmaceuticals. Many research on galactose derivatives focuses on identification, characterization, development, and mechanistic aspects of their physiological function, providing opportunities and challenges for the development of practical approaches for synthesizing galactose derivatives. This study focuses on recent advancements in enzymatic biosynthesis of galactose derivatives. Various strategies including isomerization, epimerization, transgalactosylation, and phosphorylation-dephosphorylation were extensively discussed under the perspectives of thermodynamic feasibility, theoretical yield, cost-effectiveness, and by-product elimination. Specifically, the enzymatic phosphorylation-dephosphorylation cascade is a promising enzymatic synthesis route for galactose derivatives because it can overcome the thermodynamic equilibrium of isomerization and utilize cost-effective raw materials. The study also elucidates the existing challenges and future trends in enzymatic biosynthesis of galactose derivatives. Collectively, this review provides a real-time summary aimed at promoting the practical biosynthesis of galactose derivatives through enzymatic catalysis.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: