In vivo translocator protein in females with autism spectrum disorder: a pilot study.

Autor: Tseng CJ; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Canales C; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Marcus RE; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Parmar AJ; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA., Hightower BG; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Mullett JE; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA.; Department of Pediatrics, Indiana University, Indianapolis, IN, USA., Makary MM; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA.; Systems and Biomedical Engineering Department, Faculty of Engineering, Cairo University, Cairo, Egypt., Tassone AU; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Saro HK; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Townsend PH; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Birtwell K; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Nowinski L; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Thom RP; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Palumbo ML; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Keary C; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Catana C; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., McDougle CJ; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Hooker JM; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA., Zürcher NR; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA. nzurcherwimmer@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. nzurcherwimmer@mgh.harvard.edu.; Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA. nzurcherwimmer@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Jun; Vol. 49 (7), pp. 1193-1201. Date of Electronic Publication: 2024 Apr 13.
DOI: 10.1038/s41386-024-01859-6
Abstrakt: Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio of approximately 4:1. The clinical presentation of the core symptoms of ASD can also vary between sexes. Previously, positron emission tomography (PET) studies have identified alterations in the in vivo levels of translocator protein (TSPO)-a mitochondrial protein-in primarily or only male adults with ASD, with our group reporting lower TSPO relative to whole brain mean in males with ASD. However, whether in vivo TSPO levels are altered in females with ASD, specifically, is unknown. This is the first pilot study to measure in vivo TSPO in the brain in adult females with ASD using [ 11 C]PBR28 PET-magnetic resonance imaging (MRI). Twelve adult females with ASD and 10 age- and TSPO genotype-matched controls (CON) completed one or two [ 11 C]PBR28 PET-MRI scans. Females with ASD exhibited elevated [ 11 C]PBR28 standardized uptake value ratio (SUVR) in the midcingulate cortex and splenium of the corpus callosum compared to CON. No brain area showed lower [ 11 C]PBR28 SUVR in females with ASD compared to CON. Test-retest over several months showed stable [ 11 C]PBR28 SUVR across time in both groups. Elevated regional [ 11 C]PBR28 SUVR in females with ASD stand in stark contrast to our previous findings of lower regional [ 11 C]PBR28 SUVR in males with ASD. Preliminary evidence of regionally elevated mitochondrial protein TSPO relative to whole brain mean in ASD females may reflect neuroimmuno-metabolic alterations specific to females with ASD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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