In Vitro Comparison of a Closed and Semi-closed Leaflet Design for Adult and Pediatric Transcatheter Heart Valves.
Autor: | Breitenstein-Attach A; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany. alexander.breitenstein@dhzc-charite.de.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany. alexander.breitenstein@dhzc-charite.de.; DZHK (German Centre for Cardiovascular Research), Potsdamer Str. 58, Berlin, Germany. alexander.breitenstein@dhzc-charite.de., Steitz M; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Potsdamer Str. 58, Berlin, Germany., Sun X; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Potsdamer Str. 58, Berlin, Germany., Hao Y; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany., Kiekenap J; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany., Emeis J; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany., Tuladhar SR; Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover, Germany., Berger F; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany., Schmitt B; Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin (Charité), Augustenburger Platz 1, Berlin, Germany.; Department of Pediatric Cardiology and Congenital Heart Disease, Charité - University Medicine Berlin, Augustenburger Platz 1, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Potsdamer Str. 58, Berlin, Germany. |
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Jazyk: | angličtina |
Zdroj: | Annals of biomedical engineering [Ann Biomed Eng] 2024 Aug; Vol. 52 (8), pp. 2051-2064. Date of Electronic Publication: 2024 Apr 13. |
DOI: | 10.1007/s10439-024-03502-3 |
Abstrakt: | Transcatheter heart valve replacements (TVR) are mostly designed in a closed position (c) with leaflets coaptating. However, recent literature suggests fabricating valves in semi-closed (sc) position to minimize pinwheeling. With about 100,000 children in need of a new pulmonary valve each year worldwide, this study evaluates both geometrical approaches in adult as well as pediatric size and condition. Three valves of each geometry were fabricated in adult (30 mm) and pediatric (15 mm) size, using porcine pericardium. To evaluate performance, the mean transvalvular pressure gradient (TPG), effective orifice area (EOA), and regurgitation fraction (RF) were determined in three different annulus geometries (circular, elliptic, and tilted). For both adult-sized valve geometries, the TPG (TPG (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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