Imaging gastrointestinal damage due to acute mercury poisoning using a mitochondria-targeted dual near-infrared fluorescent probe.

Autor: Zhou J; School of Pharmacy, School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, China., Li J; School of Pharmacy, School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, China., Xu X; School of Pharmacy, School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, China., Long S; School of Pharmacy, School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, China., Cui N; Baiq Biopharm (Shandong) Co., Ltd., Weifang 261000, China., Zhang Y; Qilu Institute of Technology, Jinan 250200, China., Shi L; School of Pharmacy, School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, China. Electronic address: slh2020@wfmc.edu.cn., Zhou J; School of Pharmacy, School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, China. Electronic address: zhoujin@wfmc.edu.cn.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2024 May 15; Vol. 470, pp. 134269. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1016/j.jhazmat.2024.134269
Abstrakt: Mercury (Hg) is one of the most widespread pollutants that pose serious threats to public health and the environment. People are inevitably exposed to Hg via different routes, such as respiration, dermal contact, drinking or diet. Hg poisoning could cause gingivitis, inflammation, vomiting and diarrhea, respiratory distress or even death. Especially during the developmental stage, there is considerable harm to the brain development of young children, causing serious symptoms such as intellectual disability and motor impairments, and delayed neural development. Therefore, it's of great significance to develop a specific, quick, practical and labor-saving assay for monitoring Hg 2+ . Herein, a mitochondria-targeted dual (excitation 700 nm and emission 728 nm) near-infrared (NIR) fluorescent probe JZ-1 was synthesized to detect Hg 2+ , which is a turn-on fluorescent probe designed based on the rhodamine fluorophore thiolactone, with advantages of swift response, great selectivity, and robust anti-interference capability. Cell fluorescence imaging results showed that JZ-1 could selectively target mitochondria in HeLa cells and monitor exogenous Hg 2+ . More importantly, JZ-1 has been successfully used to monitor gastrointestinal damage of acute mercury poisoning in a drug-induced mouse model, which provided a great method for sensing Hg species in living subjects, as well as for prenatal diagnosis.
Competing Interests: Declaration of Competing Interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled, “Imaging Gastrointestinal Damage Due to Acute Mercury Poisoning Using a Mitochondria-targeted Dual Near-infrared Fluorescent Probe”.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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