Curative effect of motherwort combined with ethinylestradiol-cyproterone acetate on dysfunctional uterine bleeding.
| Autor: | Tang Q; Department of Gynaecology, Zhejiang Province WuYi County First People's Hospital, Jinhua, China., Chen X; Department of Gynaecology and Obstetrics, Traditional Chinese Medical Hospital of Yongkang, Yongkang, China. |
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| Jazyk: | angličtina |
| Zdroj: | Expert review of hematology [Expert Rev Hematol] 2024 Apr-May; Vol. 17 (4-5), pp. 165-171. Date of Electronic Publication: 2024 Apr 26. |
| DOI: | 10.1080/17474086.2024.2343878 |
| Abstrakt: | Objective: This study aimed to investigate the curative effect of motherwort combined with ethinylestradiol-cyproterone acetate (EE/CPA) on dysfunctional uterine bleeding (DUB). Methods: Atotal of 68 patients with DUB were divided into a single medication group (treated with EE/CPA) and a combination medication group(treated with motherwort and EE/CPA). The clinical efficacy, uterine hemodynamic parameters, sex hormone levels, coagulation index levels, blood routine test levels, and adverse reactions of patients were evaluated. Results: After three months of treatment, total treatment response rate of the combination medication group was significantly higher than that of the single medication group. Decreased uterine volume, endometrial thickness and resistance index (RI), increased pulsatility index(PI), average flow rate, and uterine artery blood flow, as well asreduced follicle-stimulating hormone (FSH), luteinizing hormone (LH),estradiol (E2), progesterone (P), activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen (FIB), thrombin time(TT), platelet count (PLT), red blood cell (RBC), and hemoglobin (Hb)levels were witnessed in patients of the two groups. In thecombination medication group, there exhibited reduced uterine volume, endometrial thickness and RI, elevated PI, average flow rate, and uterine artery blood flow, reduced P, E2, FSH, LH, aPTT, PT, FIB, TT,PLT, RBC, and Hb levels in comparison to the single medication group. Conclusion: The combination of motherwort and EE/CPA is clinically effective in the treatment of DUB. |
| Databáze: | MEDLINE |
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