The mouse dorsal peduncular cortex encodes fear memory.

Autor:	Campos-Cardoso R; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Desa ZR; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Graduate Biomedical Sciences Program, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Fitzgerald BL; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Graduate Biomedical Sciences Program, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Moore AG; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Duhon JL; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Landar VA; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Clem RL; Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cummings KA; Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA. Electronic address: kac3@uab.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Apr 23; Vol. 43 (4), pp. 114097. Date of Electronic Publication: 2024 Apr 12.
DOI:	10.1016/j.celrep.2024.114097
Abstrakt:	The rodent medial prefrontal cortex (mPFC) is functionally organized across the dorsoventral axis, where dorsal and ventral subregions promote and suppress fear, respectively. As the ventral-most subregion, the dorsal peduncular cortex (DP) is hypothesized to function in fear suppression. However, this role has not been explicitly tested. Here, we demonstrate that the DP paradoxically functions as a fear-encoding brain region and plays a minimal role in fear suppression. By using multimodal analyses, we demonstrate that DP neurons exhibit fear-learning-related plasticity and acquire cue-associated activity across learning and memory retrieval and that DP neurons activated by fear memory acquisition are preferentially reactivated upon fear memory retrieval. Further, optogenetic activation and silencing of DP fear-related neural ensembles drive the promotion and suppression of freezing, respectively. Overall, our results suggest that the DP plays a role in fear memory encoding. Moreover, our findings redefine our understanding of the functional organization of the rodent mPFC. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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