Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure.

Autor: Labrecque L; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada., Roy MA; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada., Soleimani Dehnavi S; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada., Taghizadeh M; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada., Smirl JD; Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Concussion Research Laboratory, Faculty of Health and Exercise Science, University of British Columbia, Kelowna, BC, Canada.; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Integrated Concussion Research Program, University of Calgary, Calgary, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada., Brassard P; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
Jazyk: angličtina
Zdroj: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Oct; Vol. 44 (10), pp. 1827-1839. Date of Electronic Publication: 2024 Apr 13.
DOI: 10.1177/0271678X241247633
Abstrakt: A directional sensitivity of the cerebral pressure-flow relationship has been described using repeated squat-stands. Oscillatory lower body negative pressure (OLBNP) is a reproducible method to characterize dynamic cerebral autoregulation (dCA). It could represent a safer method to examine the directional sensitivity of the cerebral pressure-flow relationship within clinical populations and/or during pharmaceutical administration. Therefore, examining the cerebral pressure-flow directional sensitivity during an OLBNP-induced cyclic physiological stress is crucial. We calculated changes in middle cerebral artery mean blood velocity (MCAv) per alterations to mean arterial pressure (MAP) to compute ratios adjusted for time intervals (ΔMCAv T /ΔMAP T ) with respect to the minimum-to-maximum MCAv and MAP, for each OLBNP transition (0 to -90 Torr), during 0.05 Hz and 0.10 Hz OLBNP. We then compared averaged ΔMCAv T /ΔMAP T during OLBNP-induced MAP increases (INC) (ΔMCAv T / Δ MAP T INC ) and decreases (DEC) (ΔMCAv T / Δ MAP T DEC ). Nineteen healthy participants [9 females; 30 ± 6 years] were included. There were no differences in ΔMCAv T /ΔMAP T between INC and DEC at 0.05 Hz. ΔMCAv T / Δ MAP T INC (1.06 ± 0.35 vs. 1.33 ± 0.60 cm⋅s -1 /mmHg; p = 0.0076) was lower than ΔMCAv T / Δ MAP T DEC at 0.10 Hz. These results support OLBNP as a model to evaluate the directional sensitivity of the cerebral pressure-flow relationship.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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