Serum Levels of Copper and Zinc and Survival in Breast Cancer Patients.

Autor:	Szwiec M; Department of Surgery and Oncology, University of Zielona Góra, Zyty 28, 65-046 Zielona Góra, Poland., Marciniak W; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland., Derkacz R; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland., Huzarski T; Department of Clinical Genetics and Pathology, University of Zielona Góra, ul. Zyty 28, 65-046 Zielona Góra, Poland.; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Gronwald J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Cybulski C; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Dębniak T; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Jakubowska A; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Lener MR; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Falco M; Regional Oncology Centre, 71-730 Szczecin, Poland., Kładny J; Department of General and Oncological Surgery, Pomeranian Medical University, 71-252 Szczecin, Poland., Baszuk P; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Kotsopoulos J; Women's College Research Institute, Toronto, ON M5S 1B2, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada., Narod SA; Women's College Research Institute, Toronto, ON M5S 1B2, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada., Lubiński J; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland.; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Mar 29; Vol. 16 (7). Date of Electronic Publication: 2024 Mar 29.
DOI:	10.3390/nu16071000
Abstrakt:	There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included 583 patients with breast cancer diagnosed between 2008 and 2015 in the region of Szczecin, Poland. In a blood sample obtained before treatment, serum zinc and copper levels were quantified by mass spectroscopy. Each patient was assigned to one of four categories (quartiles) based on the distribution of the elements in the entire cohort. Patients were followed from diagnosis to death over a mean of 10.0 years. The 10-year overall survival was 58.3% for women in the highest and 82.1% for those in the lowest quartile of serum copper/zinc ratio ( p < 0.001). The multivariate hazard ratio (HR) for breast cancer death was 2.07 (95% CI 1.17-3.63; p = 0.01) for patients in the highest quartile of serum copper/zinc ratio compared to those in the lowest. There is evidence that the serum zinc level and copper/zinc ratio provide an independent predictive value for overall survival and breast cancer-specific survival after breast cancer diagnosis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu