Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds.

Autor: Kabieva S; Department of Chemical Technology and Ecology, Karaganda Industrial University, Temirtau 101400, Kazakhstan., Zhumanazarova G; Department of Chemical Technology and Ecology, Karaganda Industrial University, Temirtau 101400, Kazakhstan., Zhaslan R; Department of Chemical Technology and Ecology, Karaganda Industrial University, Temirtau 101400, Kazakhstan., Zhumabayeva G; Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, St. Satbaeva 2, Almaty District, Astana 010000, Kazakhstan., Ukhov A; Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia., Fedorishin D; Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia., Gubankov A; Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia., Tarikhov F; Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia., Yerkhan O; Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, St. Satbaeva 2, Almaty District, Astana 010000, Kazakhstan., Irina K; Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia., Yerkassov R; Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, St. Satbaeva 2, Almaty District, Astana 010000, Kazakhstan., Bakibaev A; Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2024 Apr 03; Vol. 29 (7). Date of Electronic Publication: 2024 Apr 03.
DOI: 10.3390/molecules29071608
Abstrakt: This study aimed to create new composite materials based on diatomite-a non-organic porous compound-through its surface modification with bioactive organic compounds, both synthetic and natural. Chloramphenicol, tetrahydroxymethylglycoluril and betulin were used as modifying substances. Composite materials were obtained by covering the diatomite surface with bioactive substance compounds as a solution and material dispersion in it. The materials were characterized by IR spectroscopy, SEM and X-ray photoelectron spectroscopy. For the biocomposites, the hemolytic effect, plasma proteins' adsorption on the surface and the antibacterial activity of the obtained materials were studied. Results show that the obtained materials are promising for medicine and agriculture.
Databáze: MEDLINE
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