Clinical [ 18 F]FSPG Positron Emission Tomography Imaging Reveals Heterogeneity in Tumor-Associated System x c - Activity.
Autor: | Sharkey AR; School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK., Koglin N; Life Molecular Imaging, 13353 Berlin, Germany., Mittra ES; Division of Molecular Imaging and Therapy, Oregon Health & Science University, Portland, OR 97239, USA., Han S; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea., Cook GJR; School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.; King's College London and Guy's and St. Thomas' PET Center, St. Thomas' Hospital, London SE1 7EH, UK., Witney TH; School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK. |
---|---|
Jazyk: | angličtina |
Zdroj: | Cancers [Cancers (Basel)] 2024 Apr 08; Vol. 16 (7). Date of Electronic Publication: 2024 Apr 08. |
DOI: | 10.3390/cancers16071437 |
Abstrakt: | Background: (4 S )-4-(3-[ 18 F]fluoropropyl)-L-glutamic acid ([ 18 F]FSPG) positron emission tomography/computed tomography (PET/CT) provides a readout of system x Methods: This retrospective analysis of prospectively collected data compared [ 18 F]FSPG PET/CT in subjects with head and neck squamous cell cancer (HNSCC, n = 5) and non-small-cell lung cancer (NSCLC, n = 10), scanned at different institutions. Using semi-automated regions of interest drawn around tumors and metastases, the maximum standardized uptake value (SUV Results: The mean administered activity of [ 18 F]FSPG was 309.3 ± 9.1 MBq in subjects with NSCLC and 285.1 ± 11.3 MBq in those with HNSCC. The biodistribution of [ 18 F]FSPG in both cohorts showed similar TACs in healthy organs from cancer patients. There was no statistically significant overall difference in the average SUV Conclusion: [ 18 F]FSPG PET/CT imaging from both NSCLC and HNSCC cohorts showed the same normal-tissue biodistribution, but marked tumor heterogeneity across subjects and between lesions. Despite rapid elimination through the urinary tract and low normal-background tissue retention, the diagnostic potential of [ 18 F]FSPG was limited by variability in tumor retention. As [ 18 F]FSPG retention is mediated by the tumor's antioxidant capacity and response to oxidative stress, this heterogeneity may provide important insights into an individual tumor's response or resistance to therapy. |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |