| Autor: |
Dellino M; Department of Interdisciplinary Medicine (DIM), University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Magazzino F; Complex Operating Unit Ginecologia E Ostetricia, Ospedale Civile Di San Dona' Di Piave (Venezia), Aulss4 Veneto Orientale, 30027 San Donà di Piave, Italy., Domenici L; Division of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56126 Pisa, Italy., Cicogna S; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', 34145 Trieste, Italy., Miano ST; Complex Operating Unit of Oncology, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy., Pignata S; Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS 'Fondazione G Pascale', 80144 Napoli, Italy., Mangili G; Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Cormio G; Department of Interdisciplinary Medicine (DIM), University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy.; Gynecologic Oncology, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy. |
| Abstrakt: |
Aggressive angiomyxoma (AAM) is a rare, locally aggressive, myxoid mesenchymal neoplasm primarily found in the pelvic and perineal regions of young adult females. It is a slow growing and locally infiltrating tumor. Preoperative diagnosis is difficult due to the rarity of these tumors and absence of characteristic signs and symptoms. The primary management is tumor excision. Incomplete excision is common because of the infiltrating nature of the neoplasm and absence of a definite capsule. Other non- surgical modalities have been employed, such as radiotherapy, embolization, GnRH analogues or other anti-estrogenic agents. Local relapses occur in 30-40% of the cases, and often appear many years (sometimes decades) after the first excision. Occasional distant metastasis has also been reported. A limited number of cases have been reported in the literature, mostly in the form of small case series or isolated case reports. Therefore, the aim of this paper by a team of experts from the MITO rare tumors group is to review clinical findings, pathologic characteristics and outcome of patients affected by this rare condition in order to be able to offer up-to-date guidance on the management of these cases. |
