'Monkeypox 2.0': Case series on a reconditioned virus causing sexually transmissible disease in urban population.

Autor:	Pakran J; Dermatology and Aesthetic center, Rashid hospital, Dubai Health Authority, Dubai, UAE., Alsaberi AM; Dermatology and Aesthetic center, Rashid hospital, Dubai Health Authority, Dubai, UAE., AlFalasi A; Dermatology and Aesthetic center, Rashid hospital, Dubai Health Authority, Dubai, UAE., Ibrahim TMKH; Dermatology and Aesthetic center, Rashid hospital, Dubai Health Authority, Dubai, UAE., Alnuaimi AAEF; Dermatology and Aesthetic center, Rashid hospital, Dubai Health Authority, Dubai, UAE., Goturu S; Derm Centre, Joseph's Polyclinic, Al Karama, UAE., Mohamed M; Department of Dermatology, Aster Clinic, Dubai, UAE., Abraham RM; Department of Dermatology, Prime Medical Center, Ajman, UAE., Sundaramurthi VL; Department of Dermatology, Prime Medical Centre, Dubai, UAE., Parambath AK; Department of Dermatology, Aster Jubilee Medical Centre, Aster Clinic, Dubai., Jose B; Department of Dermatology, Aster Medical Center, Dubai, UAE., Kamat D; Department of Dermatology, Union Medical Centre, Aster Clinic, Al Karama, Dubai., Satish TC; Department of Dermatology, Medeor Hospital, Dubai., Syeda JT; Department of Dermatology, Aster Jubilee Medical Centre, Aster Clinic, Dubai., Gul L; Department of Dermatology, Zulekha Hospital, Dubai., Mathias R; Department of Dermatology, Aster Hospital and Aster Day Surgery Centre, Mankhool, Dubai., Rasheed Vattiyamveetil S; Department of Dermatology, Abeer Alnoor Polyclinic, Dubai, UAE., Backar S; Department of Dermatology, NMC Royal Hospital, Abudhabi, UAE., Krishna CV; Department of Dermatology, Thumbay University Hospital, Ajman, UAE., Al Dhabal L; Department of Infectious disease, Rashid Hospital, Dubai Health Authority, Dubai, UAE.
Jazyk:	angličtina
Zdroj:	International journal of STD & AIDS [Int J STD AIDS] 2024 Jul; Vol. 35 (8), pp. 620-626. Date of Electronic Publication: 2024 Apr 12.
DOI:	10.1177/09564624241244832
Abstrakt:	Background: MPOX (Monkeypox) viral infection, a zoonotic disease previously confined to the African sub-continent, has caught attention worldwide recently due to its resurgence in a new 'avatar' among urban communities. Dermatologists in the U. A. E. started to see patients with fever and a self-limiting pustular necrotic rash that was negative for all other infectious investigations. Methods: We performed a prospective observational multicenter clinical study of the demographics, skin manifestations, and outcomes of patients presenting with necrotic pustular lesions and/or fever. Results: 35 cases of PCR confirmed MPOX cases, mostly in the expatriate population, were followed up and found to have high-risk heterosexual contact on an average of 1 week prior to disease onset. We found that they have characteristic annular pustular lesions with necrotic center or "Smoke ring pustules' in all cases. Lesion tenderness and predilection for the lower abdomen, pubic area, and genitalia were observed. Most cases were systemically stable, with fever lasting for an average of 4 days and elevated CRP levels. Genital lesions were prone to secondary bacterial infections. The disease was severe, with larger annular plaques in one of our patients found to be living with HIV. Conclusions: The overall prognosis in healthy individuals is good, with lesions healing within an average of 2 weeks without scarring. 'New world MPOX' should be unclassified from zoonosis to a sexually transmitted infection (STI) capable of transmission in an urban population. Our findings can help in early clinical suspicion and differentiation from other STI's for primary and secondary health care physicians. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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