Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition.

Autor: Goggans KR; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Belyaeva OV; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Klyuyeva AV; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Studdard J; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Slay A; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Newman RB; Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX, USA., VanBuren CA; Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX, USA., Everts HB; Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX, USA. heverts@twu.edu., Kedishvili NY; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. nkedishvili@uab.edu.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 Apr 12; Vol. 7 (1), pp. 453. Date of Electronic Publication: 2024 Apr 12.
DOI: 10.1038/s42003-024-06160-2
Abstrakt: The hair follicle (HF) is a self-renewing adult miniorgan that undergoes drastic metabolic and morphological changes during precisely timed cyclic organogenesis. The HF cycle is known to be regulated by steroid hormones, growth factors and circadian clock genes. Recent data also suggest a role for a vitamin A derivative, all-trans-retinoic acid (ATRA), the activating ligand of transcription factors, retinoic acid receptors, in the regulation of the HF cycle. Here we demonstrate that ATRA signaling cycles during HF regeneration and this pattern is disrupted by genetic deletion of epidermal retinol dehydrogenases 2 (RDHE2, SDR16C5) and RDHE2-similar (RDHE2S, SDR16C6) that catalyze the rate-limiting step in ATRA biosynthesis. Deletion of RDHEs results in accelerated anagen to catagen and telogen to anagen transitions, altered HF composition, reduced levels of HF stem cell markers, and dysregulated circadian clock gene expression, suggesting a broad role of RDHEs in coordinating multiple signaling pathways.
(© 2024. The Author(s).)
Databáze: MEDLINE
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