Synthesis and characterization of antimicrobial colloidal polyanilines.

Autor: Jose A; Department of Molecular Medicine and Pathology, School of Medical Sciences, the University of Auckland, Auckland 1023, New Zealand., Bansal M; School of Pharmacy, the University of Auckland, Auckland 1023, New Zealand., Svirskis D; School of Pharmacy, the University of Auckland, Auckland 1023, New Zealand., Swift S; Department of Molecular Medicine and Pathology, School of Medical Sciences, the University of Auckland, Auckland 1023, New Zealand., Gizdavic-Nikolaidis MR; Department of Molecular Medicine and Pathology, School of Medical Sciences, the University of Auckland, Auckland 1023, New Zealand; University of Belgrade, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, P. O. Box 522, Belgrade 11001, Serbia. Electronic address: m.gizdavic@auckland.ac.nz.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Jun; Vol. 238, pp. 113912. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1016/j.colsurfb.2024.113912
Abstrakt: The potential application of colloidal polyaniline (PANI) as an antimicrobial is limited by challenges related to solubility in common organic solvents, scalability, and antimicrobial potency. To address these limitations, we introduced a functionalized PANI (fPANI) with carboxyl groups through the polymerisation of aniline and 3-aminobenzoic acid in a 1:1 molar ratio. fPANI is more soluble than PANI which was determined using a qualitative study. We further enhanced the solubility and antimicrobial activity of fPANI by incorporating Ag nanoparticles onto the synthesized fPANI colloid via direct addition of 10 mM AgNO 3 . The improved solubility can be attributed to an approximately 3-fold reduction in size of particles. Mean particle sizes are measured at 1322 nm for fPANI colloid and 473 nm for fPANI-Ag colloid, showing a high dispersion and deagglomeration effect from Ag nanoparticles. Antimicrobial tests demonstrated that fPANI-Ag colloids exhibited superior potency against Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli, and Bacteriophage PhiX 174 when compared to fPANI alone. The minimum bactericidal concentration (MBC) and minimum virucidal concentration (MVC) values were halved for fPANI-Ag compared to fPANI colloid and attributed to the combination of Ag nanoparticles with the fPANI polymer. The antimicrobial fPANI-Ag colloid presented in this study shows promising results, and further exploration into scale-up can be pursued for potential biomedical applications.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Simon Swift reports financial support was provided by University of Auckland. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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