Hybrid Bioactive Hydrogel Promotes Liver Regeneration through the Activation of Kupffer Cells and ECM Remodeling After Partial Hepatectomy.

Autor: Pan Y; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., Zheng Z; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., Zhang X; School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China., Liu S; Department of Gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China., Zhuansun S; Department of Hematology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai, P. R. China., Gong S; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., Li S; Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China., Wang H; Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, P. R. China., Chen Y; School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, P. R. China., Yang T; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., Wu H; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., Xue F; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., Xia Q; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China., He K; Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, 200127, P. R. China.; Shanghai Institute of Transplantation, Shanghai, 200127, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Jul; Vol. 13 (17), pp. e2303828. Date of Electronic Publication: 2024 Apr 21.
DOI: 10.1002/adhm.202303828
Abstrakt: Partial hepatectomy is an essential surgical technique used to treat advanced liver diseases such as liver tumors, as well as for performing liver transplants from living donors. However, postoperative complications such as bleeding, abdominal adhesions, wound infections, and inadequate liver regeneration pose significant challenges and increase morbidity and mortality rates. A self-repairing mixed hydrogel (O 5 H 2 /Cu 2+ /SCCK), containing stem cell derived cytokine (SCCK) derived from human umbilical cord mesenchymal stem cells (HUMSCs) treated with the traditional Chinese remedy Tanshinone IIA (TSA), is developed. This SCCK, in conjunction with O 5 H 2 , demonstrates remarkable effects on Kupffer cell activation and extracellular matrix (ECM) remodeling. This leads to the secretion of critical growth factors promoting enhanced proliferation of hepatocytes and endothelial cells, thereby facilitating liver regeneration and repair after partial hepatectomy. Furthermore, the hydrogel, featuring macrophage-regulating properties, effectively mitigates inflammation and oxidative stress damage in the incision area, creating an optimal environment for postoperative liver regeneration. The injectability and strong adhesion of the hydrogel enables rapid hemostasis at the incision site, while its physical barrier function prevents postoperative abdominal adhesions. Furthermore, the hydrogel's incorporation of Cu 2+ provides comprehensive antibacterial effects, protecting against a wide range of bacteria types and reducing the chances of infections after surgery.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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