Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C-H Activation.

Autor: Ye Y; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China., Berry M; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Bock WJ; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Cheng K; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China., Nair SK; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Park CS; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Patman RL; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Sakata S; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Tran-Dubé M; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Donaldson JS; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States., Yang G; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China., Liu G; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China.
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2024 Apr 26; Vol. 26 (16), pp. 3338-3342. Date of Electronic Publication: 2024 Apr 12.
DOI: 10.1021/acs.orglett.4c00604
Abstrakt: Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C-H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.
Databáze: MEDLINE
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