Miniature battery-free epidural cortical stimulators.

Autor:	Woods JE; Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, USA., Singer AL; Motif Neurotech, 2450 Holcombe Blvd, Houston, TX 77021, USA.; Applied Physics Program, Rice University, 6100 Main St, Houston, TX 77005, USA., Alrashdan F; Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, USA., Tan W; Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, USA., Tan C; Department of Neurology, UTHealth McGovern Medical School, 6431 Fannin St, Houston, TX 77030, USA., Sheth SA; Department of Neurology, UTHealth McGovern Medical School, 6431 Fannin St, Houston, TX 77030, USA., Sheth SA; Department of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA., Robinson JT; Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, USA.; Motif Neurotech, 2450 Holcombe Blvd, Houston, TX 77021, USA.; Applied Physics Program, Rice University, 6100 Main St, Houston, TX 77005, USA.; Department of Bioengineering, Rice University, 6100 Main St, Houston, TX 77005, USA.; Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2024 Apr 12; Vol. 10 (15), pp. eadn0858. Date of Electronic Publication: 2024 Apr 12.
DOI:	10.1126/sciadv.adn0858
Abstrakt:	Miniaturized neuromodulation systems could improve the safety and reduce the invasiveness of bioelectronic neuromodulation. However, as implantable bioelectronic devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters in width yet can safely receive enough wireless power using magnetoelectric antennas to deliver 14.5-volt stimulation bursts, which enables it to stimulate cortical activity on-demand through the dura. The device has digitally programmable stimulation output and centimeter-scale alignment tolerances when powered by an external transmitter. We demonstrate that this device has enough power and reliability for real-world operation by showing acute motor cortex activation in human patients and reliable chronic motor cortex activation for 30 days in a porcine model. This platform opens the possibility of simple surgical procedures for precise neuromodulation.
Databáze:	MEDLINE
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