| Autor: |
Yan Q; School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China., Yuan QJ; School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China., Shatskiy A; Department of Chemistry, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden., Alvey GR; Department of Chemistry, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden., Stepanova EV; Department of Chemistry, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.; Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Avenue 30, 634050 Tomsk, Russia., Liu JQ; School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China., Kärkäs MD; Department of Chemistry, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden., Wang XS; School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China. |
| Abstrakt: |
Herein, we report a silver-catalyzed protocol for decarboxylative cross-coupling between carboxylic acids and isocyanides, leading to linear amide products through a free-radical mechanism. The disclosed approach provides a general entry to a variety of decorated amides, accommodating a diverse array of radical precursors, including aryl, heteroaryl, alkynyl, alkenyl, and alkyl carboxylic acids. Notably, the protocol proved to be efficient for decarboxylative late-stage functionalization of several elaborate pharmaceuticals, demonstrating its potential applications. |
