Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.

Autor: Mosquera-Zamudio A; Universitat de València, Valencia, Spain.; INCLIVA, Instituto de Investigación Sanitaria, Valencia, Spain., Launet L; Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, HUMAN-tech, Universitat Politècnica de València, Valencia, Spain., Colomer A; Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, HUMAN-tech, Universitat Politècnica de València, Valencia, Spain.; valgrAI: Valencian Graduate School and Research Network of Artificial Intelligence, Valencia, Spain., Wiedemeyer K; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., López-Takegami JC; Grupo de investigación IMPAC, Fundación Universitaria Sanitas, Bogotá, Colombia., Palma LF; Grupo de investigación IMPAC, Fundación Universitaria Sanitas, Bogotá, Colombia., Undersrud E; Department of Pathology, Stavanger University Hospital, Stavanger, Norway., Janssen E; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway., Brenn T; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Naranjo V; Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, HUMAN-tech, Universitat Politècnica de València, Valencia, Spain., Monteagudo C; Universitat de València, Valencia, Spain.; INCLIVA, Instituto de Investigación Sanitaria, Valencia, Spain.
Jazyk: angličtina
Zdroj: Histopathology [Histopathology] 2024 Jul; Vol. 85 (1), pp. 155-170. Date of Electronic Publication: 2024 Apr 12.
DOI: 10.1111/his.15187
Abstrakt: The histopathological classification of melanocytic tumours with spitzoid features remains a challenging task. We confront the complexities involved in the histological classification of these tumours by proposing machine learning (ML) algorithms that objectively categorise the most relevant features in order of importance. The data set comprises 122 tumours (39 benign, 44 atypical and 39 malignant) from four different countries. BRAF and NRAS mutation status was evaluated in 51. Analysis of variance score was performed to rank 22 clinicopathological variables. The Gaussian naive Bayes algorithm achieved in distinguishing Spitz naevus from malignant spitzoid tumours with an accuracy of 0.95 and kappa score of 0.87, utilising the 12 most important variables. For benign versus non-benign Spitz tumours, the test reached a kappa score of 0.88 using the 13 highest-scored features. Furthermore, for the atypical Spitz tumours (AST) versus Spitz melanoma comparison, the logistic regression algorithm achieved a kappa value of 0.66 and an accuracy rate of 0.85. When the three categories were compared most AST were classified as melanoma, because of the similarities on histological features between the two groups. Our results show promise in supporting the histological classification of these tumours in clinical practice, and provide valuable insight into the use of ML to improve the accuracy and objectivity of this process while minimising interobserver variability. These proposed algorithms represent a potential solution to the lack of a clear threshold for the Spitz/spitzoid tumour classification, and its high accuracy supports its usefulness as a helpful tool to improve diagnostic decision-making.
(© 2024 The Authors. Histopathology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: