Adult Central Neurocytomas: Clinical Features and Long-Term Treatment Outcomes in Different Age Groups.

Autor: Zhang L; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Xue J; Department of Health Management Center, Yubei Hospital, Chongqing, China., Liu A; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Li X; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: li-x-j@163.com.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2024 Jun; Vol. 186, pp. e630-e638. Date of Electronic Publication: 2024 Apr 09.
DOI: 10.1016/j.wneu.2024.04.019
Abstrakt: Background: Central neurocytomas (CNs) usually occur in young adults, and the clinical characteristics and surgical outcomes of patients in different age groups may be different.
Methods: This study was undertaken to compare the clinical and long-term treatment outcomes of patients with CNs in younger and older adult age groups.
Results: Eighty consecutive adults with CNs were included, with a mean presentation age of 28.4±7.6 years (range: 19-66 years). Thirty (37.5%) patients were <27 years old, and they tended to manifest with multiple symptoms (P = 0.002), increased intracranial pressure (ICP) symptoms (P = 0.036), an acute clinical course (P = 0.037), worse preoperative neurologic function (P = 0.023), and a larger lesion size and volume (P = 0.004 and 0.007, respectively) than their older age counterparts (≧27 years). An older onset age (P = 0.005) or age ≧27 years (P = 0.014) and worsened Karnofsky Performance Status (KPS) scale (P = 0.040) immediately after microsurgery were associated with unimproved long-term outcomes.
Conclusions: CNs in younger adult patients behave differently from those in the older age group. Surgery can halt neurologic deterioration and ensure satisfactory outcomes.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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