Exosomes encapsulated in hydrogels for effective central nervous system drug delivery.

Autor: Zakeri Z; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr., Heiderzadeh M; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr., Kocaarslan A; Chemistry Department, Faculty of Science, İstanbul Technical University, İstanbul, Turkey., Metin E; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr., Hosseini Karimi SN; School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran., Saghati S; Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Vural A; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr.; Department of Neurology, School of Medicine, KoÒ« University, Istanbul 34450, Turkey., Akyoldaş G; Department of Neurosurgery, Koç University Hospital, Istanbul 34450, Turkey., Baysal K; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr.; Department of Biochemistry, School of Medicine, Koç University, Istanbul 34450, Turkey., Yağcı Y; Chemistry Department, Faculty of Science, İstanbul Technical University, İstanbul, Turkey., Gürsoy-Özdemir Y; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr.; Department of Neurology, School of Medicine, KoÒ« University, Istanbul 34450, Turkey., Taşoğlu S; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr.; Mechanical Engineering Department, School of Engineering, Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey., Rahbarghazi R; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Sokullu E; Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey. esokullu@ku.edu.tr.; Biophysics Department, Koç University School of Medicine, Rumeli Feneri, 34450, Istanbul, Sariyer, Turkey.
Jazyk: angličtina
Zdroj: Biomaterials science [Biomater Sci] 2024 May 14; Vol. 12 (10), pp. 2561-2578. Date of Electronic Publication: 2024 May 14.
DOI: 10.1039/d3bm01055d
Abstrakt: The targeted delivery of pharmacologically active molecules, metabolites, and growth factors to the brain parenchyma has become one of the major challenges following the onset of neurodegeneration and pathological conditions. The therapeutic effect of active biomolecules is significantly impaired after systemic administration in the central nervous system (CNS) because of the blood-brain barrier (BBB). Therefore, the development of novel therapeutic approaches capable of overcoming these limitations is under discussion. Exosomes (Exo) are nano-sized vesicles of endosomal origin that have a high distribution rate in biofluids. Recent advances have introduced Exo as naturally suitable bio-shuttles for the delivery of neurotrophic factors to the brain parenchyma. In recent years, many researchers have attempted to regulate the delivery of Exo to target sites while reducing their removal from circulation. The encapsulation of Exo in natural and synthetic hydrogels offers a valuable strategy to address the limitations of Exo, maintaining their integrity and controlling their release at a desired site. Herein, we highlight the current and novel approaches related to the application of hydrogels for the encapsulation of Exo in the field of CNS tissue engineering.
Databáze: MEDLINE
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