Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study.

Autor: Melikyan ZA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Kawas CH; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Department of Neurology, University of California, Orange, California, USA.; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Paganini-Hill A; Department of Neurology, University of California, Orange, California, USA., Jiang L; Department of Epidemiology and Biostatistics, University of California, Irvine, California, USA., Bukhari S; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Montine TJ; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Mander BA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Department of Psychiatry and Human Behavior, University of California, Orange, California, USA.; Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA., Corrada MM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Department of Neurology, University of California, Orange, California, USA.; Department of Epidemiology and Biostatistics, University of California, Irvine, California, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 May; Vol. 20 (5), pp. 3495-3503. Date of Electronic Publication: 2024 Apr 11.
DOI: 10.1002/alz.13798
Abstrakt: Introduction: We investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest-old (age 90+) participants of The 90+ Study.
Methods: Participants self-reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.
Results: In 264 participants, mean age at sleep self-report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self-report and autopsy was 29 years (range: 19-40). Those reporting > 8 hours of sleep had lower likelihood of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) inclusions (OR = 0.18; CI = 0.04-0.82) and amyloid beta deposits (OR = 0.34; 95% CI = 0.12-0.94).
Discussion: Long self-reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest-old, suggesting a potential role of sleep in accumulation of dementia-related neuropathologies.
Highlights: Association of self-reported sleep with non-Alzheimer's disease neuropathologic changes has not been explored. Whether sleep duration is related to dementia neuropathologic changes decades later is unclear. Long self-reported sleep is associated with lower odds of Alzheimer's disease neuropathologic change 19 to 40 years later in the oldest-old. Long self-reported sleep is associated with lower odds of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change 19 to 40 years later in the oldest-old.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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