Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance.

Autor: Chavda VP; Department of Pharmaceutics and Pharmaceutical Technology, L.M. College of Pharmacy, Ahmedabad, India., Chaudhari AZ; Department of Pharmaceutical Chemistry, L. M. College of Pharmacy, Ahmedabad, Gujarat, India., Balar PC; Pharmacy section, L.M. College of Pharmacy, Ahmedabad, India., Gholap A; Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India., Vora LK; School of Pharmacy, Queen's University Belfast, Belfast, UK.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2024 Jun; Vol. 38 (6), pp. 3060-3079. Date of Electronic Publication: 2024 Apr 11.
DOI: 10.1002/ptr.8196
Abstrakt: Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects as human estrogens. These compounds do not directly affect biological functions but can act as agonists or antagonists depending on the level of endogenous estrogen in the body. Phytoestrogens may have an epigenetic mechanism of action independent of estrogen receptors. These compounds are found in more than 300 plant species and are synthesized through the phenylpropanoid pathway, with specific enzymes leading to various chemical structures. Phytoestrogens, primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, and lignans. Extensive research in animals and humans has demonstrated the protective effects of phytoestrogens on estrogen-dependent diseases. Clinical trials have also shown their potential benefits in conditions such as osteoporosis, Parkinson's disease, and certain types of cancer. This review provides a concise overview of phytoestrogen classification, chemical diversity, and biosynthesis and discusses the potential therapeutic effects of phytoestrogens, as well as their preclinical and clinical development.
(© 2024 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: