Maternal Childhood Adversity and Infant Epigenetic Aging: Moderation by Restless Sleep During Pregnancy.

Autor: Sosnowski DW; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health., Rojo-Wissar DM; Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University.; Bradley/Hasbro Children's Research Center, E.P. Bradley Hospital., Peng G; Department of Medical & Molecular Genetics, Indiana University School of Medicine., Parade SH; Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University.; Bradley/Hasbro Children's Research Center, E.P. Bradley Hospital., Sharkey K; Department of Medicine, The Warren Alpert Medical School of Brown University.; Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University., Hoyo C; Department of Biological Sciences, Center for Human Health and the Environment North Carolina State University., Murphy SK; Department of Obstetrics and Gynecology, Duke University School of Medicine., Hernandez RG; Department of Pediatrics, Johns Hopkins School of Medicine., Johnson SB; Department of Pediatrics, Johns Hopkins School of Medicine.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health.
Jazyk: angličtina
Zdroj: Developmental psychobiology [Dev Psychobiol] 2024 Feb; Vol. 66 (2). Date of Electronic Publication: 2024 Jan 28.
DOI: 10.1002/dev.22464
Abstrakt: Maternal exposure to childhood adversity is associated with detrimental health outcomes throughout the lifespan and may have implications for offspring. Evidence links maternal adverse childhood experiences (ACEs) to detrimental birth outcomes, yet the impact on the infant's epigenome is unclear. Moreover, maternal sleep habits during pregnancy may influence this association. Here, we explore whether restless sleep during pregnancy moderates the association between exposure to maternal childhood adversity and infant epigenetic age acceleration in 332 mother-infant dyads (56% female; 39% Black; 25% Hispanic). During the 2 nd trimester, mothers self-reported childhood adversity and past-week restless sleep; DNA methylation from umbilical vein endothelial cells was used to estimate five epigenetic clocks. Multivariable linear regression was used to test study hypotheses. Despite no evidence of main effects, there was evidence of an interaction between maternal ACEs and restless sleep in predicting infant epigenetic age acceleration using the EPIC Gestational Age clock. Only infants whose mothers reported exposure to both ACEs and restless sleep demonstrated accelerated epigenetic aging. Results provide preliminary evidence that maternal childhood adversity and sleep may influence the infant epigenome.
Competing Interests: Conflict of Interest: The authors declare that they have no competing interests.
Databáze: MEDLINE
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